A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery write by Taosheng Chen. This book was released on 2009-12-21. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery available in PDF, EPUB and Kindle. The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P
High Throughput Screening Methods
High Throughput Screening Methods - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook High Throughput Screening Methods write by Joshua A Bittker. This book was released on 2016-12-05. High Throughput Screening Methods available in PDF, EPUB and Kindle. High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
Assay Development
Assay Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Assay Development write by Ge Wu. This book was released on 2010-06-25. Assay Development available in PDF, EPUB and Kindle. Essential principles and practice of assay development The first comprehensive, integrated treatment of the subject, Assay Development: Fundamentals and Practices covers the essentials and techniques involved in carrying out an assay project in either a biotechnology/drug discovery setting or a platform setting. Rather than attempting comprehensive coverage of all assay development technologies, the book introduces the most widely used assay development technologies and illustrates the art of assay development through a few commonly encountered biological targets in assay development (e.g., proteases, kinases, ion channels, and G protein-coupled receptors). Just enough biological background for these biological targets is provided so that the reader can follow the logics of assay development. Chapters discuss: The basics of assay development, including foundational concepts and applications Commonly used instrumental methods for both biochemical assays and cell-based assays Assay strategies for protein binding and enzymatic activity Cell-based assays High-throughput screening An in-depth study of the now popular Caliper's off-chip kinase assay provides an instructive, real-world example of the assay development process.
A Practical Guide to Assay Development and High-troughput Sceening in Drug Discovery
A Practical Guide to Assay Development and High-troughput Sceening in Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook A Practical Guide to Assay Development and High-troughput Sceening in Drug Discovery write by . This book was released on 2009. A Practical Guide to Assay Development and High-troughput Sceening in Drug Discovery available in PDF, EPUB and Kindle.
High Throughput Screening: Methods, Techniques and Applications
High Throughput Screening: Methods, Techniques and Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook High Throughput Screening: Methods, Techniques and Applications write by Geoff Holdgate. This book was released on 2020-04-25. High Throughput Screening: Methods, Techniques and Applications available in PDF, EPUB and Kindle. High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In this book leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. The book provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, this book provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both todays and the hit identification laboratories of the future.
