Abc Transporters Of Human Physiology And Disease, The: Genetics And Biochemistry Of Atp Binding Cassette Transporters - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Abc Transporters Of Human Physiology And Disease, The: Genetics And Biochemistry Of Atp Binding Cassette Transporters write by Kenneth J Linton. This book was released on 2011-09-19. Abc Transporters Of Human Physiology And Disease, The: Genetics And Biochemistry Of Atp Binding Cassette Transporters available in PDF, EPUB and Kindle. ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book — that brings together state-of-the-art knowledge on ABC proteins in one volume — will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
The ABC Transporters of Human Physiology and Disease
The ABC Transporters of Human Physiology and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The ABC Transporters of Human Physiology and Disease write by Kenneth J. Linton. This book was released on 2011. The ABC Transporters of Human Physiology and Disease available in PDF, EPUB and Kindle. ATP Binding Cassette (ABC) transporters are a family of integral membrane proteins present in all cells of all species of archaea, eubacteria and eukaryota. The vast majority of these proteins control the transport across cellular membranes of molecules ranging from small ions to drugs, lipids and proteins. The human genome encodes 48 ABC transporter genes and mutations in most have been linked to disease. This book - that brings together state-of-the-art knowledge on ABC proteins in one volume - will provide students, professors and medical professionals with a background to the human ABC transporters that are known to be relevant to disease. Each of the 14 chapters is written by a leading researcher in the field. The genetics, structure and function of the proteins, and the future direction of research including the implications for human health are discussed in depth.
ABC Transporters in Human Disease
ABC Transporters in Human Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook ABC Transporters in Human Disease write by Karobi Moitra. This book was released on 2012-04-20. ABC Transporters in Human Disease available in PDF, EPUB and Kindle. The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates so far studied. The human ABC transporter superfamily contains 48 genes, subdivided into 7 subfamilies ranging from A to G (based on sequence homology of their nucleotide binding domains). The ABC proteins encoded by these genes are ATP-driven transmembrane pumps, some of which possess the capacity to efflux harmful toxic substances and therefore play a key role in xenobiotic defense. ABC proteins have been evolutionarily conserved from bacteria to humans and multiple gene duplication and deletion events in the ABC genes indicate that the process of gene evolution is still ongoing. Polymorphisms and variations in these genes are linked to variations in expression, function, drug disposition, and drug response. Single nucleotide polymorphisms (SNPs) in these genes could be markers of individual risk for adverse drug reactions or susceptibility to complex diseases. The pharmacogenetics of this unique family of transporters is still under study; however, in the context of human health, it is a well-known fact that variations in these transporters are the underlying cause for several human diseases including cystic fibrosis, Pseudoxanthoma elasticum (PXE), and X-linked adenoleukodystrophy (X-ALD). Table of Contents: Introduction to the Human ATP-Binding Cassette (ABC) Transporter Superfamily / Evolution of ABC Transporters / Overview of ABC Transporters in Human Disease / The Cystic Fibrosis Transmembrane Conductance Regulator-ABCC7 / PXE / X-linked Adrenoleukodystrophy / ABC Proteins: A Global Perspective / References / Titles of Related Interest
ABC Transporters: Biochemical, Cellular, and Molecular Aspects
ABC Transporters: Biochemical, Cellular, and Molecular Aspects - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook ABC Transporters: Biochemical, Cellular, and Molecular Aspects write by Suresh V. Ambudkar. This book was released on 1998-07-31. ABC Transporters: Biochemical, Cellular, and Molecular Aspects available in PDF, EPUB and Kindle. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchersin all fields of life sciences. Prokaryotic ABC Transporters Eukaryotic ABC Transporters Nonmammalian ABC Transport Systems Mammalian P-Glycoproteins Multidrug Resistance Associated Protein Cystic Fibrosis Transmembrane Conductance Regulator Sulfonylurea Receptor Intracellular ABC Transporters
ABC Transporters - 40 Years on
ABC Transporters - 40 Years on - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook ABC Transporters - 40 Years on write by Anthony M. George. This book was released on 2015-12-16. ABC Transporters - 40 Years on available in PDF, EPUB and Kindle. This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
