Adenosine Receptors and Parkinson's Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Adenosine Receptors and Parkinson's Disease write by Hiroshi Kase. This book was released on 1999-10-15. Adenosine Receptors and Parkinson's Disease available in PDF, EPUB and Kindle. This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease. Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function Proposes a hypothesis of adenosine A2A receptor function in the striatum Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints
Adenosine Receptors in Health and Disease
Adenosine Receptors in Health and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Adenosine Receptors in Health and Disease write by Constance N. Wilson. This book was released on 2009-07-28. Adenosine Receptors in Health and Disease available in PDF, EPUB and Kindle. Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
The Adenosine Receptors
The Adenosine Receptors - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Adenosine Receptors write by Pier Andrea Borea. This book was released on 2018-07-28. The Adenosine Receptors available in PDF, EPUB and Kindle. This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Atlas of Neuroactive Substances and Their Receptors in the Rat
Atlas of Neuroactive Substances and Their Receptors in the Rat - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Atlas of Neuroactive Substances and Their Receptors in the Rat write by Masaya Tohyama. This book was released on 1998. Atlas of Neuroactive Substances and Their Receptors in the Rat available in PDF, EPUB and Kindle. The rat is probably the most widely used experimental system in neurobiology. Several anatomical atlases of the rat's nervous system already exist, but this atlas is unique in that it maps the distribution of all neuroactive substances--transmitters, growth factors, modulators, hormones, and peptides--and their receptors by brain region. It begins with a useful overview of neurotransmission mechanisms. The entire brain is then presented in highly visual three-color sections. The atlas covers the synthesis, distribution, and functions of each class of substances in intricate detail. The authors follow this with an analysis of the structure, subtypes, and distribution of receptors. The volume will be an invaluable reference work for all researchers in neuropharmacology, neurobiology, and neuropathology.
Homeostatic Control of Brain Function
Homeostatic Control of Brain Function - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Homeostatic Control of Brain Function write by Detlev Boison. This book was released on 2016. Homeostatic Control of Brain Function available in PDF, EPUB and Kindle. Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
