Advances in Metallodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Advances in Metallodrugs write by Shahid Ul-Islam. This book was released on 2020-07-08. Advances in Metallodrugs available in PDF, EPUB and Kindle. This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.
Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile
Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile write by Maria Contel. This book was released on 2019-10-01. Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile available in PDF, EPUB and Kindle. For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.
Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells
Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells write by Kenneth Kam-Wing Lo. This book was released on 2016-12-30. Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells available in PDF, EPUB and Kindle. Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells Foscuses on the fundamentals and their potential therapeutic and diagnostic applications Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents
Unconventional Anticancer Metallodrugs and Strategies to Improve Their Pharmacological Profile
Unconventional Anticancer Metallodrugs and Strategies to Improve Their Pharmacological Profile - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Unconventional Anticancer Metallodrugs and Strategies to Improve Their Pharmacological Profile write by Maria Contel. This book was released on 2019. Unconventional Anticancer Metallodrugs and Strategies to Improve Their Pharmacological Profile available in PDF, EPUB and Kindle. For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.
Metals in Medicine
Metals in Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Metals in Medicine write by James C. Dabrowiak. This book was released on 2017-05-02. Metals in Medicine available in PDF, EPUB and Kindle. Working from basic chemical principles, Metals in Medicine, 2nd Edition describes a wide range of metal-based agents for treating and diagnosing disease. Thoroughly revised and restructured to reflect significant research activity and advances, this new edition contains extensive updates and new pedagogical features while retaining the popular feature boxes and end-of-chapter problems of the first edition. Topics include: Metallo-Drugs and their action Platinum drugs for treating cancer Anticancer agents beyond cisplatin including ruthenium, gold, titanium and gallium Responsive Metal Complexes Treating arthritis and diabetes with metal complexes Metal complexes for killing bacteria, parasites and viruses Metal ion imbalance and its links to diseases including Alzheimer's, Wilson's and Menkes disease Metal complexes for detecting disease Nanotechnology in medicine Now in full colour, Metals in Medicine, 2nd Edition employs real-life applications and chapter-end summaries alongside feature boxes and problems. It provides a complete and methodical examination of the use of metal complexes in medicine for advanced undergraduate and postgraduate students in medicinal inorganic chemistry, bioinorganic chemistry, biochemistry, pharmacology, biophysics, biology and bioengineering. It is also an invaluable resource for academic researchers and industrial scientists in inorganic chemistry, medicinal chemistry and drug development.
