Recent Advancement in Prodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Recent Advancement in Prodrugs write by Kamal Shah. This book was released on 2020. Recent Advancement in Prodrugs available in PDF, EPUB and Kindle. Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
Prodrugs and Targeted Delivery
Prodrugs and Targeted Delivery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Prodrugs and Targeted Delivery write by Jarkko Rautio. This book was released on 2011-01-11. Prodrugs and Targeted Delivery available in PDF, EPUB and Kindle. This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Prodrugs
Prodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Prodrugs write by Valentino Stella. This book was released on 2007-03-12. Prodrugs available in PDF, EPUB and Kindle. These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.
Hydrolysis in Drug and Prodrug Metabolism
Hydrolysis in Drug and Prodrug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Hydrolysis in Drug and Prodrug Metabolism write by Bernard Testa. This book was released on 2003-08. Hydrolysis in Drug and Prodrug Metabolism available in PDF, EPUB and Kindle. Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Advances in Prodrugs
Advances in Prodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Advances in Prodrugs write by Claudiu Trandafir Supuran. This book was released on 2024-07-01. Advances in Prodrugs available in PDF, EPUB and Kindle. Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools. Highlights chemistry and pharmacology-related aspects, offering a versatile tool for the readers involved in prodrug development and study Discusses in depth treatment of several activation mechanisms and applications for disease treatments Covers a range of topics from basic contents, design, mechanisms of actions to current applications in drugs
