Alzheimer's Disease Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Alzheimer's Disease Drug Development write by Jeffrey Cummings. This book was released on 2022-03-31. Alzheimer's Disease Drug Development available in PDF, EPUB and Kindle. Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.
Alzheimer's Disease Drug Development
Alzheimer's Disease Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Alzheimer's Disease Drug Development write by Jeffrey Cummings. This book was released on 2022-03-31. Alzheimer's Disease Drug Development available in PDF, EPUB and Kindle. Alzheimer's Disease (AD) is a growing global public health challenge. The development of new therapies is urgently needed, and a complex ecosystem of organizations has grown to facilitate AD drug discovery and development. Masterfully collating information on the drug development ecosystem, this book emphasizes the contributions of each aspect in the pipeline with a uniform approach to chapters, enabling readers to access relevant information quickly. Topics covered include the use of non-clinical laboratory studies, biomarker development, artificial intelligence, design and management of clinical trials, and funding and financing models. Also discussed is the critical role of advocacy fundraising for drug development. With the approval of aducanumab, the function of the ecosystem has become apparent. This is a definitive overview of how the ecosystem works in transferring an AD drug from its discovery in the laboratory through clinical trial testing to regulatory review and eventual marketing.
Biomarkers for Alzheimer’s Disease Drug Development
Biomarkers for Alzheimer’s Disease Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomarkers for Alzheimer’s Disease Drug Development write by Robert Perneczky. This book was released on 2018-03-07. Biomarkers for Alzheimer’s Disease Drug Development available in PDF, EPUB and Kindle. This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders write by Adeboye Adejare. This book was released on 2016-09-20. Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders available in PDF, EPUB and Kindle. Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
Drug Design and Discovery in Alzheimer’s Disease
Drug Design and Discovery in Alzheimer’s Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Design and Discovery in Alzheimer’s Disease write by Atta-ur Rahman. This book was released on 2015-06-27. Drug Design and Discovery in Alzheimer’s Disease available in PDF, EPUB and Kindle. Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
