Anhedonia: Preclinical, Translational, and Clinical Integration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anhedonia: Preclinical, Translational, and Clinical Integration write by Diego A. Pizzagalli. This book was released on 2022-08-08. Anhedonia: Preclinical, Translational, and Clinical Integration available in PDF, EPUB and Kindle. Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.
Emerging Neurobiology of Antidepressant Treatments
Emerging Neurobiology of Antidepressant Treatments - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Emerging Neurobiology of Antidepressant Treatments write by Michael Browning. This book was released on . Emerging Neurobiology of Antidepressant Treatments available in PDF, EPUB and Kindle.
Next Generation Antidepressants
Next Generation Antidepressants - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Next Generation Antidepressants write by Chad E. Beyer. This book was released on 2010-05-20. Next Generation Antidepressants available in PDF, EPUB and Kindle. The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of discoveries soon to influence their practice.
Obsessive-compulsive Disorder
Obsessive-compulsive Disorder - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Obsessive-compulsive Disorder write by Christopher Pittenger. This book was released on 2017. Obsessive-compulsive Disorder available in PDF, EPUB and Kindle. Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.
Anhedonia: A Comprehensive Handbook Volume I
Anhedonia: A Comprehensive Handbook Volume I - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anhedonia: A Comprehensive Handbook Volume I write by Michael S. Ritsner. This book was released on 2014-07-08. Anhedonia: A Comprehensive Handbook Volume I available in PDF, EPUB and Kindle. This is the first comprehensive two-volume collection on anhedonia, a disorder that played an important role in psychopathology theories at the beginning of the twentieth century. Anhedonia is a condition in which the capacity of pleasure is partially or completely lost, and it refers to both a personality trait, and a “state symptom” in various neuropsychiatric and physical disorders. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Over the past three decades cognitive psychology and behavioral neuroscience have expanded our understanding of anhedonia and other reward-related processes. The aim of this new two-volume collection on anhedonia is to highlight the contributions of eminent scientists in this field as well as to provide readers with comprehensive accounts of recent developments as perceived by the authors. This monograph is divided into five parts. Volume I contains parts one and two (Conceptual Issues and Neurobiological Advances) including 14 chapters that serve as an introduction and overview of conceptual issues. Volume II contains three parts (Anhedonia in Psychotic Disorders, Anhedonia in Mood and Personality Disorders, and Anhedonia in Neurological and Physical Disorders) including 15 chapters that provide an overview of the construct, measurement of anhedonia in schizophrenia spectrum disorders, hedonic capacity and related factors in schizophrenia and schizoaffective disorder, anhedonia as an indicator of genetic liability for schizophrenia, and as a trait marker for depression, the role of an anhedonia in trauma-related disorders, anorexia nervosa, stress-induced eating disorders, schizotypal traits and risk of suicide. This book will be of interest to a broad spectrum of readers including psychiatrists, psychologists, neurologists, neuroscientists, endocrinologists, pharmacologists, general practitioners, geriatricians, graduate students, and health care providers in the fields of mental health.
