Anticancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer write by David Servan-Schreiber. This book was released on 2008. Anticancer available in PDF, EPUB and Kindle. The author describes his treatment for brain cancer, challenges beliefs about the body's ability to heal, identifies the environmental and lifestyle factors that promote cancer growth, and outlines conventional and alternative therapies.
Anticancer Drug Development Guide
Anticancer Drug Development Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer Drug Development Guide write by Beverly A. Teicher. This book was released on 2004-02-01. Anticancer Drug Development Guide available in PDF, EPUB and Kindle. This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Fate and Effects of Anticancer Drugs in the Environment
Fate and Effects of Anticancer Drugs in the Environment - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Fate and Effects of Anticancer Drugs in the Environment write by Ester Heath. This book was released on 2020-01-01. Fate and Effects of Anticancer Drugs in the Environment available in PDF, EPUB and Kindle. The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.
Principles of Cancer Treatment and Anticancer Drug Development
Principles of Cancer Treatment and Anticancer Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles of Cancer Treatment and Anticancer Drug Development write by Wolfgang Link. This book was released on 2019-09-10. Principles of Cancer Treatment and Anticancer Drug Development available in PDF, EPUB and Kindle. This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
Medicinal Chemistry of Anticancer Drugs
Medicinal Chemistry of Anticancer Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Medicinal Chemistry of Anticancer Drugs write by Carmen Avendaño. This book was released on 2015-06-11. Medicinal Chemistry of Anticancer Drugs available in PDF, EPUB and Kindle. Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
