Anticancer Drug Development Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer Drug Development Guide write by Beverly A. Teicher. This book was released on 2013-11-11. Anticancer Drug Development Guide available in PDF, EPUB and Kindle. Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest, detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing, explain the criteria for success, and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.
Anticancer Drug Development Guide
Anticancer Drug Development Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer Drug Development Guide write by Beverly A. Teicher. This book was released on 2004-02-01. Anticancer Drug Development Guide available in PDF, EPUB and Kindle. This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Anticancer Drug Development Guide
Anticancer Drug Development Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer Drug Development Guide write by Beverly A. Teicher. This book was released on 2014-01-15. Anticancer Drug Development Guide available in PDF, EPUB and Kindle.
Anticancer Drug Development Guide
Anticancer Drug Development Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Anticancer Drug Development Guide write by Beverly A. Teicher. This book was released on 2004-02-01. Anticancer Drug Development Guide available in PDF, EPUB and Kindle. This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Principles of Anticancer Drug Development
Principles of Anticancer Drug Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Principles of Anticancer Drug Development write by Elizabeth Garrett-Mayer. This book was released on 2010-12-29. Principles of Anticancer Drug Development available in PDF, EPUB and Kindle. A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
