Applications of Antisense Therapies to Restenosis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Applications of Antisense Therapies to Restenosis write by LeRoy E. Rabbani. This book was released on 2012-12-06. Applications of Antisense Therapies to Restenosis available in PDF, EPUB and Kindle. Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.
Antisense Research and Application
Antisense Research and Application - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antisense Research and Application write by Stanley T. Crooke. This book was released on 2012-12-06. Antisense Research and Application available in PDF, EPUB and Kindle. Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Manual of Antisense Methodology
Manual of Antisense Methodology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Manual of Antisense Methodology write by Gunther Hartmann. This book was released on 2012-12-06. Manual of Antisense Methodology available in PDF, EPUB and Kindle. In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.
Applications of Biotechnology in Cardiovascular Therapeutics
Applications of Biotechnology in Cardiovascular Therapeutics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Applications of Biotechnology in Cardiovascular Therapeutics write by Kewal K. Jain. This book was released on 2011-07-25. Applications of Biotechnology in Cardiovascular Therapeutics available in PDF, EPUB and Kindle. For physicians, surgeons, and scientists working on cardiovascular disorders, Applications of Biotechnology in Cardiovascular Therapeutics serves as an invaluable reference by collecting the essential writings of Dr. Kewal K. Jain on the topics of biotechnology as they relate to cardiovascular disease. This thorough volume includes such subjects as biotechnology and therapeutic delivery to the cardiovascular system, cell-selective targeted drug delivery, cell and gene therapies, including antisense and RNA interference, cutting-edge gene therapy approaches, as well as personalized cardiology as a way of integrating new technologies into the selection of the best possible treatment for an individual patient. Selected references from recent literature are collected for each chapter, and the text is supplemented by a variety of useful tables and figures. Comprehensive and up-to-date, Applications of Biotechnology in Cardiovascular Therapeutics will be tremendously useful for those working in life sciences and the pharmaceutical sciences, and the inclusion of some basics of cardiovascular diseases will greatly benefit nonmedical readers as well.
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors write by Eric Wickstrom. This book was released on 2020-08-13. Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors available in PDF, EPUB and Kindle. An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors. Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors furnishes a historical overview of genetic therapy highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications illustrates for new practitioners how each stage of genetic therapy is developed details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.
