Applications of RNA-Seq in Biology and Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Applications of RNA-Seq in Biology and Medicine write by Irina Vlasova-St. Louis. This book was released on 2021-10-13. Applications of RNA-Seq in Biology and Medicine available in PDF, EPUB and Kindle. This book evaluates and comprehensively summarizes the scientific findings that have been achieved through RNA-sequencing (RNA-Seq) technology. RNA-Seq transcriptome profiling of healthy and diseased tissues allows FOR understanding the alterations in cellular phenotypes through the expression of differentially spliced RNA isoforms. Assessment of gene expression by RNA-Seq provides new insight into host response to pathogens, drugs, allergens, and other environmental triggers. RNA-Seq allows us to accurately capture all subtypes of RNA molecules, in any sequenced organism or single-cell type, under different experimental conditions. Merging genomics and transcriptomic profiling provides novel information underlying causative DNA mutations. Combining RNA-Seq with immunoprecipitation and cross-linking techniques is a clever multi-omics strategy assessing transcriptional, post-transcriptional and post-translational levels of gene expression regulation.
Evolution of Translational Omics
Evolution of Translational Omics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Evolution of Translational Omics write by Institute of Medicine. This book was released on 2012-09-13. Evolution of Translational Omics available in PDF, EPUB and Kindle. Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Applications of RNA-Seq and Omics Strategies
Applications of RNA-Seq and Omics Strategies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Applications of RNA-Seq and Omics Strategies write by Fabio Marchi. This book was released on 2017-09-13. Applications of RNA-Seq and Omics Strategies available in PDF, EPUB and Kindle. The large potential of RNA sequencing and other "omics" techniques has contributed to the production of a huge amount of data pursuing to answer many different questions that surround the science's great unknowns. This book presents an overview about powerful and cost-efficient methods for a comprehensive analysis of RNA-Seq data, introducing and revising advanced concepts in data analysis using the most current algorithms. A holistic view about the entire context where transcriptome is inserted is also discussed here encompassing biological areas with remarkable technological advances in the study of systems biology, from microorganisms to precision medicine.
Biological Sequence Analysis
Biological Sequence Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biological Sequence Analysis write by Richard Durbin. This book was released on 1998-04-23. Biological Sequence Analysis available in PDF, EPUB and Kindle. Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
RNA-seq Data Analysis
RNA-seq Data Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA-seq Data Analysis write by Eija Korpelainen. This book was released on 2014-09-19. RNA-seq Data Analysis available in PDF, EPUB and Kindle. The State of the Art in Transcriptome AnalysisRNA sequencing (RNA-seq) data offers unprecedented information about the transcriptome, but harnessing this information with bioinformatics tools is typically a bottleneck. RNA-seq Data Analysis: A Practical Approach enables researchers to examine differential expression at gene, exon, and transcript le
