ATP and the Heart - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook ATP and the Heart write by Joanne S. Ingwall. This book was released on 2012-12-06. ATP and the Heart available in PDF, EPUB and Kindle. ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.
Regulation of Coronary Blood Flow
Regulation of Coronary Blood Flow - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Regulation of Coronary Blood Flow write by Michitoshi Inoue. This book was released on 2013-11-09. Regulation of Coronary Blood Flow available in PDF, EPUB and Kindle. Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Cellular and Molecular Pathobiology of Cardiovascular Disease
Cellular and Molecular Pathobiology of Cardiovascular Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cellular and Molecular Pathobiology of Cardiovascular Disease write by Monte Willis. This book was released on 2013-12-23. Cellular and Molecular Pathobiology of Cardiovascular Disease available in PDF, EPUB and Kindle. Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Cardiac Energy Metabolism in Health and Disease
Cardiac Energy Metabolism in Health and Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cardiac Energy Metabolism in Health and Disease write by Gary D. Lopaschuk. This book was released on 2014-08-22. Cardiac Energy Metabolism in Health and Disease available in PDF, EPUB and Kindle. The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
The Scientist's Guide to Cardiac Metabolism
The Scientist's Guide to Cardiac Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Scientist's Guide to Cardiac Metabolism write by Michael Schwarzer. This book was released on 2015-11-04. The Scientist's Guide to Cardiac Metabolism available in PDF, EPUB and Kindle. The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. - Provides a quick and comprehensive introduction into cardiac metabolism - Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs - Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function - Includes historical perspectives that reference important investigators that have contributed to the development of the field
