Behavioral and Neural Genetics of Zebrafish - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Behavioral and Neural Genetics of Zebrafish write by Robert T. Gerlai. This book was released on 2020-04-03. Behavioral and Neural Genetics of Zebrafish available in PDF, EPUB and Kindle. Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Psychophysics and Genetics of Zebrafish Visual Behavior
Psychophysics and Genetics of Zebrafish Visual Behavior - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Psychophysics and Genetics of Zebrafish Visual Behavior write by Michael Brian Orger. This book was released on 2005. Psychophysics and Genetics of Zebrafish Visual Behavior available in PDF, EPUB and Kindle. A central goal of neuroscience is to understand the neural basis of behavior. The zebrafish is a vertebrate model system that allows behavior to be studied using both systems and molecular genetic approaches. Here we present a psychophysical and genetic analysis of optomotor behavior in zebrafish larvae. By applying psychophysical methods developed for primates to zebrafish we have demonstrated than motion detection in zebrafish uses mechanisms that are broadly similar to humans. The larvae are susceptible to visual illusions that indicate that they detect Fourier motion energy in visual scenes. They also respond to non-Fourier motion, an ability that is believed to depend on visual cortex in humans. Different visual behaviors in the fish use different chromatic information. The optomotor response, in particular, is colorblind and pools signals from longer wavelength cones, while excluding shorter wavelength inputs. Motion processing seems to be functionally similar between higher and lower vertebrates despite large differences in neuroanatomy. Using an automated assay, we have conducted a large-scale genetic screen for recessive mutants affecting the optomotor response. Testing these mutants with a battery of behavioral assays allows us to categorize them into motor and visual system mutants, as well as some that are specific to the optomotor response. Many have normal visual system anatomy, but some are missing specific cell-types or have defects in axon target selection.
The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish
The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish write by Allan V. Kalueff. This book was released on 2017-02-06. The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish available in PDF, EPUB and Kindle. Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
The world according to zebrafish: How neural circuits generate behaviour
The world according to zebrafish: How neural circuits generate behaviour - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The world according to zebrafish: How neural circuits generate behaviour write by Gonzalo G. De Polavieja. This book was released on 2014-11-07. The world according to zebrafish: How neural circuits generate behaviour available in PDF, EPUB and Kindle. Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Behavioral Neurogenetics
Behavioral Neurogenetics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Behavioral Neurogenetics write by John F. Cryan. This book was released on 2012-05-04. Behavioral Neurogenetics available in PDF, EPUB and Kindle. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
