Antibiotic Drug Resistance - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antibiotic Drug Resistance write by José-Luis Capelo-Martínez. This book was released on 2019-09-24. Antibiotic Drug Resistance available in PDF, EPUB and Kindle. This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications
Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications write by Hartmut Derendorf. This book was released on 2019-07-11. Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications available in PDF, EPUB and Kindle. Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Synthesis of β-Lactam Antibiotics
Synthesis of β-Lactam Antibiotics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Synthesis of β-Lactam Antibiotics write by Alle Bruggink. This book was released on 2011-06-27. Synthesis of β-Lactam Antibiotics available in PDF, EPUB and Kindle. Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Antibiotic Discovery and Development
Antibiotic Discovery and Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Antibiotic Discovery and Development write by Thomas J. Dougherty. This book was released on 2011-12-18. Antibiotic Discovery and Development available in PDF, EPUB and Kindle. This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Penicillins and Cephalosporins
Penicillins and Cephalosporins - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Penicillins and Cephalosporins write by Robert B. Morin. This book was released on 2014-05-10. Penicillins and Cephalosporins available in PDF, EPUB and Kindle. Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
