Biologic and Gene Therapy of Autoimmune Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biologic and Gene Therapy of Autoimmune Disease write by C. Garrison Fathman. This book was released on 2000-01-01. Biologic and Gene Therapy of Autoimmune Disease available in PDF, EPUB and Kindle. The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.
Biological and Gene Therapy of Autoimmune Disease
Biological and Gene Therapy of Autoimmune Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biological and Gene Therapy of Autoimmune Disease write by C. G. Fathman. This book was released on 2000. Biological and Gene Therapy of Autoimmune Disease available in PDF, EPUB and Kindle.
Biologics and Biosimilars
Biologics and Biosimilars - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biologics and Biosimilars write by Xiaodong Feng. This book was released on 2022-06-13. Biologics and Biosimilars available in PDF, EPUB and Kindle. Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.
Gene Therapy of Autoimmune Disease
Gene Therapy of Autoimmune Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Gene Therapy of Autoimmune Disease write by Gerald J. Prud'homme. This book was released on 2005-07-13. Gene Therapy of Autoimmune Disease available in PDF, EPUB and Kindle. Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gene Therapy for Autoimmune and Inflammatory Diseases
Gene Therapy for Autoimmune and Inflammatory Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Gene Therapy for Autoimmune and Inflammatory Diseases write by Yuti Chernajovsky. This book was released on 2011-01-28. Gene Therapy for Autoimmune and Inflammatory Diseases available in PDF, EPUB and Kindle. In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
