Biomechanics of the Central Nervous System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomechanics of the Central Nervous System write by Alf Breig. This book was released on 1960. Biomechanics of the Central Nervous System available in PDF, EPUB and Kindle.
Neural Tissue Biomechanics
Neural Tissue Biomechanics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neural Tissue Biomechanics write by Lynne E. Bilston. This book was released on 2011-07-23. Neural Tissue Biomechanics available in PDF, EPUB and Kindle. Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.
Biomechanics of the Nervous System
Biomechanics of the Nervous System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomechanics of the Nervous System write by Michael O. Shacklock. This book was released on 2007. Biomechanics of the Nervous System available in PDF, EPUB and Kindle. Breig's understanding of how the nervous system functions mechanically lead to new concepts in manual and musculoskeletal medicine. This summary work includes content from two books, Biomechanics of the central nervous system (1960) and Adverse mechanical tension in the nervous system (1978); photoelastic models of stress behavior; cranial nerve and nerve root movement; spinal cord biomechanics; movement of meningeal tissues and intraneural blood vessel behavior, cauda equina biomechanics, sliding and tension of the neural tissues; and analysis of lumbopelvic movement with neurodynamic testing.
Biomechanics of the Central Nervous System. Some Basic Normal and Pathologic Phenomena. (Translation by Victor Braxton.) [A Thesis.].
Biomechanics of the Central Nervous System. Some Basic Normal and Pathologic Phenomena. (Translation by Victor Braxton.) [A Thesis.]. - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomechanics of the Central Nervous System. Some Basic Normal and Pathologic Phenomena. (Translation by Victor Braxton.) [A Thesis.]. write by Alf BREIG. This book was released on 1960. Biomechanics of the Central Nervous System. Some Basic Normal and Pathologic Phenomena. (Translation by Victor Braxton.) [A Thesis.]. available in PDF, EPUB and Kindle.
Cell Biomechanics of the Central Nervous System
Cell Biomechanics of the Central Nervous System - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cell Biomechanics of the Central Nervous System write by Kristin Briana Bernick. This book was released on 2011. Cell Biomechanics of the Central Nervous System available in PDF, EPUB and Kindle. Traumatic brain injury (TBI) is a significant cause of death and morbidity in both the civilian and military populations. The major causes of TBI, such as motor vehicle accidents, falls, sports concussions, and ballistic and explosive blast threats for military personnel, are well established and extensively characterized; however, there remains much to be learned about the specific mechanisms of damage leading to brain injury, especially at the cellular level. In order to understand how cells of the central nervous system (CNS) respond to mechanical insults and stimuli, a combined modeling/experimental approach was adopted. A computational framework was developed to accurately model how cells deform under various macroscopically imposed loading conditions. In addition, in vitro (cell culture) models were established to investigate damage responses to biologically relevant mechanical insults. In order to develop computational models of cell response to mechanical loading, it is essential to have accurate material properties for all cells of interest. In this work, the mechanical responses of neurons and astrocytes were quantified using atomic force microscopy (AFM) at three different loading rates and under relaxation to enable characterization of both the elastic and viscous components of the cell response. AFM data were used to calibrate an eight-parameter rheological model implemented in the framework of a commercial finite element package (Abaqus). Model parameters fit to the measured responses of neurons and astrocytes provide a quantitative measure of homogenized nonlinear viscoelastic properties for each cell type. In order to ensure that the measured responses could be considered representative of cell populations in their physiological environment, cells were also grown and tested on substrates of various stiffness, with the softest substrate mimicking the stiffness of brain tissue. Results of this study showed both the morphology and measured force response of astrocytes to be significantly affected by the stiffness of their substrate, with cells becoming increasingly rounded on soft substrates. Results of simulations suggested that changes in cell morphology were able to account for the observed changes in AFM force response, without significant changes to the cell material properties. In contrast, no significant changes in cell morphology were observed for neurons. These results highlight the importance of growing cells in a biologically relevant environment when studying mechanically mediated responses, such as TBI. To address this requirement, we developed two model systems with CNS cells grown in soft, 3D gels to investigate damage arising from dynamic compressive loading and from a shock pressure wave. These damage protocols, coupled with the single cell computational models, provide a new tool set for characterizing damage mechanisms in CNS cells and for studying TBI in highly controllable in vitro conditions.
