Biopharmaceutics Modeling and Simulations - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biopharmaceutics Modeling and Simulations write by Kiyohiko Sugano. This book was released on 2012-07-31. Biopharmaceutics Modeling and Simulations available in PDF, EPUB and Kindle. A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.
Basic Pharmacokinetics and Pharmacodynamics
Basic Pharmacokinetics and Pharmacodynamics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Basic Pharmacokinetics and Pharmacodynamics write by Sara E. Rosenbaum. This book was released on 2012-09-10. Basic Pharmacokinetics and Pharmacodynamics available in PDF, EPUB and Kindle. With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations write by Sheila Annie Peters. This book was released on 2012-02-17. Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations available in PDF, EPUB and Kindle. The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference a valuable asset for general or novice readers without a PBPK background along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.
Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture
Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture write by Marianthi G. Ierapetritou. This book was released on 2016-08-23. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture available in PDF, EPUB and Kindle. This thorough volume aims to provide pharmaceutical engineers with an introduction to the current state of the art in modeling and simulation of pharmaceutical processes and to summarize a number of practical applications of relevant methodologies in drug product development. Chapters include explorations of simulation and modeling methodologies, data collection and analysis, development of novel sensing techniques, development and integration of individual unit models, optimization approaches for data-based models, design space evaluation techniques, informatics-based methodologies, and emerging topics in pharmaceutical process development. As a part of the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and implementation advice that will make the transition into the laboratory as smooth as possible. Authoritative and cutting edge, Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture seeks to promote research into process systems methodologies and their application in pharmaceutical product and process development, which will undoubtedly become an increasingly important area in the future.
Oral Drug Absorption
Oral Drug Absorption - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Oral Drug Absorption write by Jennifer B. Dressman. This book was released on 2016-04-19. Oral Drug Absorption available in PDF, EPUB and Kindle. Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
