Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance write by Peter Igaz. This book was released on 2015-11-25. Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance available in PDF, EPUB and Kindle. MicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
MicroRNAs in Medicine
MicroRNAs in Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNAs in Medicine write by Charles H. Lawrie. This book was released on 2013-10-30. MicroRNAs in Medicine available in PDF, EPUB and Kindle. MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
The origin, function and diagnostic potential of extracellular microRNA in human body fluids
The origin, function and diagnostic potential of extracellular microRNA in human body fluids - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The origin, function and diagnostic potential of extracellular microRNA in human body fluids write by Andrey Turchinovich. This book was released on 2014-07-28. The origin, function and diagnostic potential of extracellular microRNA in human body fluids available in PDF, EPUB and Kindle. Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific ‘by-products’ of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication.
Circulating MicroRNAs
Circulating MicroRNAs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Circulating MicroRNAs write by Takahiro Ochiya. This book was released on 2013-05-30. Circulating MicroRNAs available in PDF, EPUB and Kindle. microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.
MicroRNA Expression Detection Methods
MicroRNA Expression Detection Methods - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNA Expression Detection Methods write by Zhiguo Wang. This book was released on 2009-12-23. MicroRNA Expression Detection Methods available in PDF, EPUB and Kindle. MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of - nucleotides, have rapidly emerged as the central players in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiov- cular disorders, metabolic disturbances, etc. Particular expression pro?les have been associated with particular pathological states. Expression pro?ling of miR- NAs have therefore become extremely important not only for fundamentalists but also for clinicians. However, the methodologies used for detecting protein-coding mRNAs cannot be directly applied to miRNAs because of their small size. Over the past years, researchers have made great efforts to developing techniques suitable for miRNA detection and quanti?cation; a wide spectrum of creative and inno- tive techniques (more than 30 different methods) have been invented and validated. It has come to the time now to summarize these methods and present them in an orderly manner for better understanding and utilization of these methods to miRNA research and applications. In particular, the development of methods for quantifying circulating miRNAs opens up a fascinating opportunity for realizing miRNA as diagnostic and prognostic biomarkers of human disease. A book on this subject may help boosting up the passion of researchers to further improve the existing techniques and develop more new methods to ?t to new application needs. These considerations prompted us and urged us to undertake the work: writing a book focusing on miRNA expression detection methods.
