Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II write by . This book was released on 2024-01-10. Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II available in PDF, EPUB and Kindle. This Research Topic is the second volume of the “Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy". Please see Volume I here. Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy. This research topic aims to focus on the advances in the discoveries of novel biomarkers for predicting response to cancer immunotherapy in various tumors. We welcome the submission of original research and review articles that include biomarkers in clinical study and applications, as well as technologies or discoveries in experimental approaches.
Novel Biomarkers for Predicting Response to Cancer Immunotherapy
Novel Biomarkers for Predicting Response to Cancer Immunotherapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Novel Biomarkers for Predicting Response to Cancer Immunotherapy write by Jinghua Pan. This book was released on 2023-07-11. Novel Biomarkers for Predicting Response to Cancer Immunotherapy available in PDF, EPUB and Kindle. Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy.
Novel biomarkers in tumor immunity and immunotherapy
Novel biomarkers in tumor immunity and immunotherapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Novel biomarkers in tumor immunity and immunotherapy write by Takaji Matsutani. This book was released on 2024-07-26. Novel biomarkers in tumor immunity and immunotherapy available in PDF, EPUB and Kindle. Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly effective against many types of cancer, yet durable responses are limited to a subset of patients highlighting the need for the development of effective biomarkers to predict prognosis and efficacy. Currently, PD-L1 expression in tumors, microsatellite instability (MSI) or mismatch repair deficiency (dMMR), and tumor mutation burden (TMB) are known as biomarkers for cancer immunotherapy but are not sufficient. Combination therapy with immune checkpoint inhibitors and chemotherapy or radiation therapy, as well as diverse therapies targeting intra-tumoral regulatory T cells have been described, but there are currently no unifying biomarkers that are applicable to clinically, a simple, fast, non-invasive method that can yield biomarkers of disease with a minimal adverse effect on patients is desirable. Recent findings suggest that the balancing of effector T cells and regulatory cells in the tumor microenvironment is associated with cancer progression and prognosis. Cells and molecules involved in the control of cancer are complex, and a better understanding of the tumor immune environment will lead to the development of truly effective biomarkers. This topic will focus on novel biomarkers that predict efficacy, prognosis, or the development of adverse events in various cancer immunotherapies, and extensive basic research leading to the development of biomarkers. Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic. We expect a wide range of research, not only in serology, genetics, and immunocytochemistry but also in bacterial flora. Research on the development of novel assays and bioinformatics methods is also welcome: • Non-invasive biomarkers for cancer immunotherapy. • Bulk RNA-seq, scRNA-seq, or Rep-seq methods. • Correlation of tumor immune cells with gut microbiota in tumor immunotherapy. • Impact of Teff and Treg balance in the tumor microenvironment on tumor prognosis. • Inflammatory and immune signatures associated with drug response versus resistance in cancer.
Community series in immunotherapy with checkpoint inhibitors for non-small cell lung cancer, colon cancer and esophageal cancer, volume II
Community series in immunotherapy with checkpoint inhibitors for non-small cell lung cancer, colon cancer and esophageal cancer, volume II - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Community series in immunotherapy with checkpoint inhibitors for non-small cell lung cancer, colon cancer and esophageal cancer, volume II write by Xuelei Ma. This book was released on 2023-07-27. Community series in immunotherapy with checkpoint inhibitors for non-small cell lung cancer, colon cancer and esophageal cancer, volume II available in PDF, EPUB and Kindle.
Handbook of Therapeutic Biomarkers in Cancer
Handbook of Therapeutic Biomarkers in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Therapeutic Biomarkers in Cancer write by Sherry X. Yang. This book was released on 2021-02-01. Handbook of Therapeutic Biomarkers in Cancer available in PDF, EPUB and Kindle. This book provides a comprehensive overview of the fast-evolving subject of clinical application of cancer therapeutic biomarkers. The second edition captures significant progress of cancer immunotherapy and emphasizes the genetic basis for selective cancer treatment. It covers an in-depth insight on biomarkers across a broad area of cancer research and oncology with a wealth of integrated genetic and molecular information about specific therapies by a multidisciplinary team of internationally recognized experts. Each chapter focuses on a class of targeted, immunologic, or chemotherapy agents and their companion biomarkers that predict response, benefit or resistance, and severe adverse event. The book will serve as a handbook for health professionals and scientists on the current applicable biomarkers in the management of cancer. The vision into the systemic classification and statistical consideration of therapeutic biomarkers summarized by the book editors and chapter authors will help advance precision medicine—a precisely tailored cancer treatment strategy for cancer patient care.
