Conformation in Biology and Drug Design - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Conformation in Biology and Drug Design write by Victor J. Hruby. This book was released on 1985. Conformation in Biology and Drug Design available in PDF, EPUB and Kindle.
Conformation in Biology and Drug Design
Conformation in Biology and Drug Design - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Conformation in Biology and Drug Design write by Sidney Udenfriend. This book was released on 2014-05-10. Conformation in Biology and Drug Design available in PDF, EPUB and Kindle. The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.
Multifaceted Roles of Crystallography in Modern Drug Discovery
Multifaceted Roles of Crystallography in Modern Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Multifaceted Roles of Crystallography in Modern Drug Discovery write by Giovanna Scapin. This book was released on 2015-02-27. Multifaceted Roles of Crystallography in Modern Drug Discovery available in PDF, EPUB and Kindle. The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.
Structure-Based Drug Discovery
Structure-Based Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Structure-Based Drug Discovery write by Roderick E Hubbard. This book was released on 2007-10-31. Structure-Based Drug Discovery available in PDF, EPUB and Kindle. Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences.
The Peptides: Conformation in biology and drug design
The Peptides: Conformation in biology and drug design - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Peptides: Conformation in biology and drug design write by Erhard Gross. This book was released on 1979. The Peptides: Conformation in biology and drug design available in PDF, EPUB and Kindle.
