Control and Prediction of Solid-State of Pharmaceuticals - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Control and Prediction of Solid-State of Pharmaceuticals write by Rajni Miglani Bhardwaj. This book was released on 2016-02-02. Control and Prediction of Solid-State of Pharmaceuticals available in PDF, EPUB and Kindle. This thesis investigates a range of experimental and computational approaches for the discovery of solid forms. Furthermore, we gain, as readers, a better understanding of the key factors underpinning solid-structure and diversity. A major part of this thesis highlights experimental work carried out on two structurally very similar compounds. Another important section involves looking at the influence of small changes in structure and substituents on solid-structure and diversity using computational tools including crystal structure prediction, PIXEL calculations, Xpac, Mercury and statistical modeling tools. In addition, the author presents a fast validated method for solid-state form screening using Raman microscopy on multi-well plates to explore the experimental crystallization space. This thesis illustrates an inexpensive, practical and accurate way to predict the crystallizability of organic compounds based on molecular structure alone, and additionally highlights the molecular factors that inhibit or promote crystallization.
Experimental and Computational Approaches for Control and Prediction of Solid-state of Pharmaceuticals
Experimental and Computational Approaches for Control and Prediction of Solid-state of Pharmaceuticals - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Experimental and Computational Approaches for Control and Prediction of Solid-state of Pharmaceuticals write by Rajni Miglani Bhardwaj. This book was released on 2013. Experimental and Computational Approaches for Control and Prediction of Solid-state of Pharmaceuticals available in PDF, EPUB and Kindle.
Solid State Characterization of Pharmaceuticals
Solid State Characterization of Pharmaceuticals - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Solid State Characterization of Pharmaceuticals write by Richard A. Storey. This book was released on 2011-03-31. Solid State Characterization of Pharmaceuticals available in PDF, EPUB and Kindle. The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection
Computational Pharmaceutical Solid State Chemistry
Computational Pharmaceutical Solid State Chemistry - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Computational Pharmaceutical Solid State Chemistry write by Yuriy A. Abramov. This book was released on 2016-04-27. Computational Pharmaceutical Solid State Chemistry available in PDF, EPUB and Kindle. This book is the first to combine computational material science and modeling of molecular solid states for pharmaceutical industry applications. • Provides descriptive and applied state-of-the-art computational approaches and workflows to guide pharmaceutical solid state chemistry experiments and to support/troubleshoot API solid state selection • Includes real industrial case examples related to application of modeling methods in problem solving • Useful as a supplementary reference/text for undergraduate, graduate and postgraduate students in computational chemistry, pharmaceutical and biotech sciences, and materials science
Solid State Development and Processing of Pharmaceutical Molecules
Solid State Development and Processing of Pharmaceutical Molecules - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Solid State Development and Processing of Pharmaceutical Molecules write by Michael Gruss. This book was released on 2021-11-15. Solid State Development and Processing of Pharmaceutical Molecules available in PDF, EPUB and Kindle. Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
