Controlled Human Inhalation-Exposure Studies at EPA - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Controlled Human Inhalation-Exposure Studies at EPA write by National Academies of Sciences, Engineering, and Medicine. This book was released on 2017-04-10. Controlled Human Inhalation-Exposure Studies at EPA available in PDF, EPUB and Kindle. The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.
Controlled Human Inhalation-Exposure Studies at EPA
Controlled Human Inhalation-Exposure Studies at EPA - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Controlled Human Inhalation-Exposure Studies at EPA write by National Academies of Sciences, Engineering, and Medicine. This book was released on 2017-05-10. Controlled Human Inhalation-Exposure Studies at EPA available in PDF, EPUB and Kindle. The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.
The Inside Story
The Inside Story - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Inside Story write by . This book was released on 1993. The Inside Story available in PDF, EPUB and Kindle.
Intentional Human Dosing Studies for EPA Regulatory Purposes
Intentional Human Dosing Studies for EPA Regulatory Purposes - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Intentional Human Dosing Studies for EPA Regulatory Purposes write by National Research Council. This book was released on 2004-06-04. Intentional Human Dosing Studies for EPA Regulatory Purposes available in PDF, EPUB and Kindle. The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.
America's Children and the Environment
America's Children and the Environment - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook America's Children and the Environment write by U.s. Environmental Protection Agency. This book was released on 2017-05-31. America's Children and the Environment available in PDF, EPUB and Kindle. "America's Children and the Environment (ACE)" is EPA's report presenting data on children's environmental health. ACE brings together information from a variety of sources to provide national indicators in the following areas: Environments and Contaminants, Biomonitoring, and Health. Environments and Contaminants indicators describe conditions in the environment, such as levels of air pollution. Biomonitoring indicators include contaminants measured in the bodies of children and women of child-bearing age, such as children's blood lead levels. Health indicators report the rates at which selected health outcomes occur among U.S. children, such as the annual percentage of children who currently have asthma. Accompanying each indicator is text discussing the relevance of the issue to children's environmental health and describing the data used in preparing the indicator. Wherever possible, the indicators are based on data sources that are updated in a consistent manner, so that indicator values may be compared over time.
