Development and Implementation of Trajectory Optimization Technologies for Cranial Stereotactic Radiation Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Development and Implementation of Trajectory Optimization Technologies for Cranial Stereotactic Radiation Therapy write by R Lee MacDonald. This book was released on 2018. Development and Implementation of Trajectory Optimization Technologies for Cranial Stereotactic Radiation Therapy available in PDF, EPUB and Kindle. Radiotherapy treatment planning optimization employs metrics for the quantification of plan quality indicators based on a set of input desired criteria by the planner. Patient-specificity in current practice is limited to the customization and refinement of input optimization criteria to contextualize relative urgency. The arc geometry and machine trajectory in radiotherapy planning can create additional opportunities for optimization on a patient-specific basis. This work proposes novel technologies capable of leveraging new degrees of freedom in the domain of radiotherapy to improve radiotherapy plan quality. A series of four manuscripts form the basis for this thesis. The first manuscript, "Overlap Guided Fixed Patient Support Positioning Optimization for Cranial SRT", is an investigation into the optimization of couch rotation angle in the standard cranial stereotactic VMAT template to reduce the presence of overlap of sensitive structures with the targeted tissues in the aperture of the radiation beam. The second manuscript, "Dynamic Collimator Trajectory Algorithm for Multiple Metastases Dynamic Conformal Arc Treatment Planning", demonstrates a novel method of reducing the presence of uncollimated non-target anatomy from the aperture of the radiation beam and increases the efficacy of collimation by optimizing the rotation angles of the multi-leaf collimator. Additionally, it proposes the use of dynamically updated collimator angle throughout delivery to maximize the capacity of this optimization. The third manuscript, "Intra-Arc Binary Collimation Algorithm for the Optimization of Stereotactic Radiotherapy Treatment of Multiple Metastases with Multiple Prescriptions", demonstrates a novel method of aperture design in multiple metastases cranial radiosurgery which maximizes the presence of conformal aperture to increase the efficiency of monitor units, while regularly shielding targets completely to modulate dose to meet target prescription and healthy tissues sparing. Finally, the fourth manuscript, "CODA: Combined Optimization of Dynamic Axes", is the first investigation into the synergistic optimization of the rotation angle of the collimator, the rotation angle of the treatment couch, and the rotation angle of the gantry to accomplish the objectives of normal tissue sparing and treatment efficiency using a novel organization of cost function and trajectory design. These manuscripts form the basis for automated optimization of linear accelerator trajectories in cranial radiosurgery. Their implementation can result in significant increases in plan quality when compared to state of the art conventional treatment planning. The introduction of these additional forms of optimization can be used to mitigate the effects of inter-planner variation in plan quality by automating the steps performed in expert-planning.
Treatment Plan Optimization and Delivery Using Dynamic Gantry-couch Trajectories
Treatment Plan Optimization and Delivery Using Dynamic Gantry-couch Trajectories - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Treatment Plan Optimization and Delivery Using Dynamic Gantry-couch Trajectories write by Joel Mullins. This book was released on 2021. Treatment Plan Optimization and Delivery Using Dynamic Gantry-couch Trajectories available in PDF, EPUB and Kindle. "In radiation therapy, trajectory-based delivery involves the dynamic motion of linear accelerator components combined with continuous arc radiation delivery. The increased complexity of the delivery may yield dosimetric advantages, but the delivery technique has not seen clinical implementation. The purpose of this thesis work is to provide support for clinical implementation of trajectory-based treatment delivery, through the application of novel trajectories, implementation of a trajectory-based optimization algorithm, and verification of the treatment delivery accuracy under dynamic conditions.The initial study in this thesis applied translational couch trajectories to reduce the effective source-to-axis distance (SAD), with potential benefits due to the decreased projected size of the multileaf collimator and an increased effective dose rate. A noncoplanar trajectory was applied to patients presented with cranial targets, and treatment plans were optimized at shortened and standard SAD. Through comparisons to clinical treatment plans, the shortened SAD treatment plans yielded a fraction size dependent decrease in the treatment delivery time due to the increased effective dose rate. The noncoplanar trajectories yielded comparable plan quality to the clinical deliveries.The next study focused on the novel implementation of a trajectory optimization algorithm for concurrent gantry and couch rotation. The optimization algorithm implemented uses the column generation approach to simultaneously determine the trajectory path during volumetric modulated arc therapy optimization (simTr-VMAT). With comparisons to coplanar VMAT plans and to randomly generated trajectories that represent the solution space for the optimization problem, the simTr-VMAT optimization methodology was validated.The complex trajectory paths resulting from the simTr-VMAT optimizations were observed as a potential source of dose delivery inaccuracy. A trajectory smoothing procedure was implemented, and the base and smoothed treatment plans were delivered on the TrueBeam linear accelerator. The trajectory smoothing retained the treatment plan quality of the base trajectories. The delivery accuracy was largely within combined standard uncertainty. A systematic difference between measurement and calculation was observed that requires further investigation. The smoothed trajectory plans yielded improved agreement with measurement compared to the base trajectory plans.The final study investigated the gantry-couch rotation angle coordinate system. Trajectory optimizations were performed under a cartesian and spherical coordinate system for seven patient cases, using a overlap score map approach. The arclength between adjacent control points showed less variation for cases where the cartesian trajectory included arc segments with couch-only rotations. The objective function value was improved for 4 out of 7 patient cases for the spherical trajectories, but limitations of two-step trajectory optimization approaches were observed.Through the research presented in this thesis, clinical advantages of trajectory-based delivery were demonstrated, as well as the importance of trajectory smoothing to improve the accuracy of dose delivery. This work helps to pave the way towards the clinical implementation of trajectory-based treatment delivery"--
Handbook of Robotic and Image-Guided Surgery
Handbook of Robotic and Image-Guided Surgery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Robotic and Image-Guided Surgery write by Mohammad Abedin-Nasab. This book was released on 2019-09-25. Handbook of Robotic and Image-Guided Surgery available in PDF, EPUB and Kindle. Handbook of Robotic and Image-Guided Surgery provides state-of-the-art systems and methods for robotic and computer-assisted surgeries. In this masterpiece, contributions of 169 researchers from 19 countries have been gathered to provide 38 chapters. This handbook is 744 pages, includes 659 figures and 61 videos. It also provides basic medical knowledge for engineers and basic engineering principles for surgeons. A key strength of this text is the fusion of engineering, radiology, and surgical principles into one book. A thorough and in-depth handbook on surgical robotics and image-guided surgery which includes both fundamentals and advances in the field A comprehensive reference on robot-assisted laparoscopic, orthopedic, and head-and-neck surgeries Chapters are contributed by worldwide experts from both engineering and surgical backgrounds
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT)
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) write by Dwight E. Heron, MD, MBA, FACRO, FACR. This book was released on 2018-09-28. Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) available in PDF, EPUB and Kindle. Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) is a comprehensive guide for the practicing physician and medical physicist in the management of complex intracranial and extracranial disease. It is a state-of-the-science book presenting the scientific principles, clinical background and procedures, treatment planning, and treatment delivery of SRS and SBRT for the treatment of tumors throughout the body. This unique textbook is enhanced with supplemental video tutorials inclusive to the resource. Beginning with an overview of SRS and SBRT, Part I contains insightful coverage on topics such as the evolving radiobiological principles that govern treatment, imaging, the treatment planning process, technologies and equipment used, as well as focused chapters on quality assurance, quality management, and patient safety. Part II contains the clinical application of SRS and SBRT for tumors throughout the body including those in the brain, head and neck, lung, pancreas, adrenal glands, liver, prostate, cervix, spine, and in oligometastatic disease. Each clinical chapter includes an introduction to the disease site, followed by a thorough review of all indications and exclusion criteria, in addition to the important considerations for patient selection, treatment planning and delivery, and outcome evaluation. These chapters conclude with a detailed and site-specific dose constraints table for critical structures and their suggested dose limits. International experts on the science and clinical applications of these treatments have joined together to assemble this must-have book for clinicians, physicists, and other radiation therapy practitioners. It provides a team-based approach to SRS and SBRT coupled with case-based video tutorials in disease management, making this a unique companion for the busy radiosurgical team. Key Features: Highlights the principles of radiobiology and radiation physics underlying SRS and SBRT Presents and discusses the expected patient outcomes for each indicated disease site and condition including a detailed analysis of Quality of Life (QOL) and Survival Includes information about technologies used for the treatment of SRS and SBRT Richly illustrated with over 110 color images of the equipment, process flow diagrams and procedures, treatment planning techniques and dose distributions 7 high-quality videos reviewing anatomy, staging, treatment simulation and planning, contouring, and management pearls Dose constraint tables at the end of each clinical chapter listing critical structures and their appropriate dose limits Includes access to the fully-searchable downloadable eBook
The Use of Computers in Radiation Therapy
The Use of Computers in Radiation Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Use of Computers in Radiation Therapy write by Wolfgang Schlegel. This book was released on 2012-12-06. The Use of Computers in Radiation Therapy available in PDF, EPUB and Kindle. Computers have had and will continue to have a tremendous impact on professional activity in almost all areas. This applies to radiological medicine and in particular to radiation therapy. This book compiles the most recent developments and results of the application of computers and computer science as presented at the XIIIth International Conference on the Use of Computers in Radiation Therapy in Heidelberg, Germany. The text of both oral presentations and posters is included. The book is intended for computer sientists, medical physicists, engineers and physicians in the field of radiation therapy and provides a comprehensive survey of the entire field.
