Handbook of Drug Metabolism, Third Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Drug Metabolism, Third Edition write by Paul G. Pearson. This book was released on 2019-05-20. Handbook of Drug Metabolism, Third Edition available in PDF, EPUB and Kindle. This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Human Drug Metabolism
Human Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Human Drug Metabolism write by Michael D. Coleman. This book was released on 2010-03-30. Human Drug Metabolism available in PDF, EPUB and Kindle. Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Drug Metabolism and Pharmacokinetics Quick Guide
Drug Metabolism and Pharmacokinetics Quick Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism and Pharmacokinetics Quick Guide write by Siamak Cyrus Khojasteh. This book was released on 2011-04-07. Drug Metabolism and Pharmacokinetics Quick Guide available in PDF, EPUB and Kindle. Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Introduction to Drug Metabolism
Introduction to Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Introduction to Drug Metabolism write by G. Gordon Gibson. This book was released on 2001. Introduction to Drug Metabolism available in PDF, EPUB and Kindle. Of drug-metabolising reactions. p. 25.
Drug Metabolism in Drug Design and Development
Drug Metabolism in Drug Design and Development - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism in Drug Design and Development write by Donglu Zhang. This book was released on 2007-11-16. Drug Metabolism in Drug Design and Development available in PDF, EPUB and Kindle. The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
