Drug Metabolism in Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism in Diseases write by Wen Xie. This book was released on 2016-09-12. Drug Metabolism in Diseases available in PDF, EPUB and Kindle. Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. - Written and edited by leaders in drug metabolism from academia and industry - Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more - Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic
Drug Metabolism in Diseases
Drug Metabolism in Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism in Diseases write by Wen Xie. This book was released on 2025-10-01. Drug Metabolism in Diseases available in PDF, EPUB and Kindle. "Drug metabolism in diseases", now in second edition, provides pharmaceutical scientists and biologists with the needed foundational knowledge required to understand the interplay between diseases and physiological conditions, how they impact drug metabolism and disposition, and its implications in personalized treatment. The book has been expanded with six new chapters, and completely updated with the scientific findings since the first edition published in 2016. The new chapters in the book cover drug metabolism in metabolic syndrome , transplant patients, geriatric patients, the developmental regulation of drug metabolism and disposition, the effect of gut microbiota on xenobiotic and endobiotic metabolism, the regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways, and drug metabolism in HIV patients. All other chapters in the first edition like drug metabolism in pregnancy, pediatric patients, patients of cardiovascular disease, and kidney diseases were completely updated to include the latest research results and references. "Drug metabolism in diseases" is a comprehensive reference on the mutual effect between drug metabolism and diseases, which has great implications in precision medicine and therapeutic development. Pharmaceutical scientists and drug metabolism researchers in academia and corporate R&D departments will benefit from the expanded coverage provided by expert authors. Research physicians interested in better understand the impact of diseases in drug metabolism will also benefit from the comprehensive overview of the area.• Provides a comprehensive overview of how diseases and physiological conditions impact drug metabolism and disposition and its implications in personalized treatment• Provides insights into leveraging drug metabolizing enzymes and transporters as therapeutic targets• Includes six new chapters and updates across all content to provide a current and updated view on this rapidly evolving research topic
Rational Therapeutics for Infants and Children
Rational Therapeutics for Infants and Children - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Rational Therapeutics for Infants and Children write by Institute of Medicine. This book was released on 2000-04-07. Rational Therapeutics for Infants and Children available in PDF, EPUB and Kindle. The Institute of Medicine's (IOM's) Roundtable on Research and Development of Drugs, Biologics, and Medical Devices evolved from the Forum on Drug Development, which was established in 1986. Sponsor representatives and IOM determined the importance of maintaining a neutral setting for discussions regarding long-term and politically sensitive issues justified the need to revise and enhance past efforts. The new Roundtable is intended to be a mechanism by which a broad group of experts from the public* and private sectors can be convened to conduct a dialogue and exchange information related to the development of drugs, biologics, and medical devices. Members have expertise in clinical medicine, pediatrics, clinical pharmacology, health policy, health insurance, industrial management, and product development; and they represent interests that address all facets of public policy issues. From time to time, the Roundtable requests that a workshop be conducted for the purpose of exploring a specific topic in detail and obtaining the views of additional experts. The first workshop for the Roundtable was held on April 14 and 15, 1998, and was entitled Assuring Data Quality and Validity in Clinical Trials for Regulatory Decision Making. The summary on that workshop is available from IOM. This workshop summary covers the second workshop, which was held on May 24 and 25, 1999, and which was aimed at facilitating the development and proper use of drugs, biologics, and medical devices for infants and children. It explores the scientific underpinnings and clinical needs, as well as the regulatory, legal, and ethical issues, raised by this area of research and development.
Diseases of the Brain, Head and Neck, Spine 2020–2023
Diseases of the Brain, Head and Neck, Spine 2020–2023 - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Diseases of the Brain, Head and Neck, Spine 2020–2023 write by Juerg Hodler. This book was released on 2020-02-14. Diseases of the Brain, Head and Neck, Spine 2020–2023 available in PDF, EPUB and Kindle. This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism write by Aparajita Dey. This book was released on 2013-02-12. Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism available in PDF, EPUB and Kindle. The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
