Establishing Songbirds as an Animal Model for the Development of Human Speech Prosthesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Establishing Songbirds as an Animal Model for the Development of Human Speech Prosthesis write by Daril EVan Brown II. This book was released on 2022. Establishing Songbirds as an Animal Model for the Development of Human Speech Prosthesis available in PDF, EPUB and Kindle. Losing the ability to speak--whether from stroke, traumatic brain injury, or other neurological disorders--significantly reduces a person's quality of life. Research studies demonstrate proof-of-concept Speech-Synthesis Brain-Machine Interface (BMI) systems, but several limitations impede their clinical viability. A major rate limiting factor impeding progress in developing speech prosthesis is the lack of an established animal model to ask basic science questions regarding the neural encoding of vocal communication. This dissertation aims to address this gap by establishing songbirds as an animal model for a human speech prosthesis. Songbirds are a well-established model for vocal learning, and their motor nuclei are homologous to the human motor cortex with respect to function and gene transcription. This work builds upon this basis to demonstrate songbirds' suitability as a preclinical model to accelerate the development of speech-prosthesis technology. First, we answer basic science questions regarding nuclei important for the song system by characterizing neurophysiological similarities and differences with respect to human motor areas during vocalization. In analyses of data recorded with electrodes chronically implanted in the premotor region HVC of awake free-behaving zebra finches, we detail novel Local Field Potential (LFP) signatures correlated to vocal behavior. These LFP signatures are decomposed using signal processing methods to characterize their relation to vocal production. This work found that HVC exhibits many remarkably similar spectral characteristics to LFP in human motor cortex during speech. Next, we developed proof-of-concept systems that demonstrate algorithms feasible for real time vocal BMIs. Utilizing simple algorithms, we show that HVC LFP features can be leveraged to predict vocal activity. These algorithms can be run in real time to predict both the identity and onset of syllable production. Leveraging these simple algorithms, we analyze preliminary system requirements necessary for decoding vocal elements. The methods developed to leverage these LFP features to predict vocal behavior can be implemented in real-time and suggest a path for developing a similar system for humans. Finally, this thesis details both software and hardware designs to enable reproduction and wider adoption of the songbird animal model by the speech prosthesis research field. We developed novel methods to partition freely produced vocal behavior data based on the subjects' behavior, which are provided to the field as open-source software. We also designed an integrated counterweight and tether management system that dramatically lowers the stress on chronically implanted small animal subjects. Collectively, these works enrich the literature connecting human and avian vocal-motor production, and we believe strengthen the argument for utilizing songbirds to supplement human speech prosthesis research.
Automatic Labeling and Representation of Birdsong for Speech Prosthesis
Automatic Labeling and Representation of Birdsong for Speech Prosthesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Automatic Labeling and Representation of Birdsong for Speech Prosthesis write by Aparna Srinivasan. This book was released on 2021. Automatic Labeling and Representation of Birdsong for Speech Prosthesis available in PDF, EPUB and Kindle. Songbirds are widely studied as an animal model to accelerate the development of neurally driven speech prostheses. Consequently, the analyses carried out on the songbird model are dependent on high-quality labeled datasets. Building such datasets is usually laborious, as it involves manually annotating their vocal behavior, after which, neural activity can be decoded into vocalizations. However, the direct translation to vocal behavior is quite challenging since songbird vocalizations are typically recorded at high sampling rates to capture the rapid changes in behavior. In this thesis, such problems are addressed using data-driven approaches. To reduce the efforts involved in manual annotations, deep learning models are explored for automatic labeling of vocalizations. A model based on convolutional and recurrent layers called TweetyNet is trained with a small amount of manually labeled data comprising features from audio. It is shown to achieve high frame-level sensitivity and high temporal precision in annotating the vocalizations of adult male zebra finches whose recordings were collected in-house. Alternatively, a WaveNet-based fully convolutional model trained directly on audio, is also shown to provide high temporal precision in annotations. To minimize the complexities involved in the direct translation of neural activity to behavior, an intermediate stage is introduced in the neural decoding pipeline. This stage will encode a low-dimensional representation of the behavior from which vocalizations can be reconstructed. A Vector Quantized Variational Autoencoder is trained to learn the latent representation of zebra finch vocalizations. Additionally, from these latent representations, novel stimuli are generated for use in psychophysical experiments. While the stereotypical behavior of songbirds is widely studied, for practical vocal prostheses it is equally important to be able to decode the non-stereotypical behavior like calls, which can be of multiple types. The different calls in zebra finches are identified using Uniform Manifold Approximation and Projection, and the spike counts are determined from their corresponding neural activity. Gaussian classification of spike counts is shown to achieve high accuracy corroborating the mutual information existing between spike counts and call type. These techniques and analyses are believed to provide insights for the development of songbird vocal prostheses.
The Neuroethology of Birdsong
The Neuroethology of Birdsong - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Neuroethology of Birdsong write by Jon T. Sakata. This book was released on 2020-03-24. The Neuroethology of Birdsong available in PDF, EPUB and Kindle. Vocal signals are central for social communication across a wide range of vertebrate species; consequently, it is critical to understand the mechanisms underlying the learning, control, and evolution of vocal communication. Songbirds are at the forefront of research into such neural mechanisms. Indeed, songbirds provide a particularly important model system for this endeavor because of the many parallels between birdsong and human speech. Specifically, (1) songbirds are one of the few vertebrate species that, like humans, learn their vocal signals during development, (2) the processes of song learning and control in songbirds shares many parallels with the process of speech acquisition in humans, and (3) there exist deep homologies between the circuits for the learning, control, and processing of vocal signals across songbirds and humans. In addition, because of the diversity of songbirds and song learning strategies, songbirds offer a powerful model system to use the comparative method to reveal mechanisms underlying the evolution of song learning and production. Taken together, research on songbirds can not only reveal general principles underlying vertebrate vocal communication but can also provide insight into potential mechanisms underlying the learning, control, and processing of speech. This volume will cover a range of topics in birdsong spanning multiple level of analysis. Chapters will be authored by the world’s leading experts on birdsong and will provide comprehensive reviews of the processes underlying song learning, of the neural circuits for song learning and control as well as for the extraction and processing of song information, of the selection pressures underlying song evolution, and of genetic and molecular mechanisms underlying the learning and evolution of song. The primary goals of this volume are to provide comprehensive, integrative, and comparative perspectives on birdsong and to underscore the importance of birdsong to biomedical research, evolutionary biology, and behavioral, systems, and computational neuroscience.The target audience of this volume will be graduate students, postdoctoral fellows, and established academics and neuroscientists who are interested in mechanisms of communication from an integrative and comparative perspective. The volume is intended to function as a high-profile and contemporary reference on current work related to the learning, control, processing, and evolution of birdsong. This volume will have broad appeal to comparative and sensory biologists, neurophysiologists, and behavioral, systems, and cognitive neuroscientists who attend meetings such as the Society for Neuroscience, the International Society for Neuroethology, and the Society for Integrative and Comparative Biology. Because of the relevance of birdsong research to understanding human speech, it is likely that the volume will also be of interest to speech researchers and clinicians researching communication, motor, and sensory processing disorders.
Research Awards Index
Research Awards Index - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Research Awards Index write by . This book was released on 1989. Research Awards Index available in PDF, EPUB and Kindle.
Research Grants Index
Research Grants Index - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Research Grants Index write by National Institutes of Health (U.S.). Division of Research Grants. This book was released on 1975. Research Grants Index available in PDF, EPUB and Kindle.
