Evaluating Synergy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Evaluating Synergy write by Ming Tan. This book was released on 2024-04-08. Evaluating Synergy available in PDF, EPUB and Kindle. Containing the historical and statistical information necessary to choose an analysis method and successful drug combination, Evaluating Synergy provides a systematic introduction of statistical methods for optimally designing and analyzing combination studies in cancer, anti-viral, and other therapeutic areas. This practical guide provides scientists in translational research, data analysts, and statisticians in cancer research with a detailed discussion on the challenging case of three or multi-drug combinations. Numerous examples accompany a presentation that illustrates experimental design considerations for modern drug analysis.
Drug Synergism and Dose-Effect Data Analysis
Drug Synergism and Dose-Effect Data Analysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Synergism and Dose-Effect Data Analysis write by Ronald J. Tallarida. This book was released on 2000-07-21. Drug Synergism and Dose-Effect Data Analysis available in PDF, EPUB and Kindle. Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.
Synergy Value and Strategic Management
Synergy Value and Strategic Management - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Synergy Value and Strategic Management write by Stefano Garzella. This book was released on 2016-08-29. Synergy Value and Strategic Management available in PDF, EPUB and Kindle. This book addresses synergy management, which poses an important challenge for firms, advisors and practitioners involved in mergers and acquisitions (M&A). Synergy plays a key role in M&A contexts, both in the decision-making process and, subsequently, in the integration phase. However, despite the fact that synergy value is commonly regarded as one of the key success factors in M&A, research shows that firms generally fail to achieve the expected synergy. The extant literature is characterized by a lack of comprehensive models of synergy management: the assessment of synergy value remains a “black box” for scholars and practitioners alike. The authors provide a comprehensive framework for synergy management by integrating findings from prior research and various disciplines. The framework highlights the main dimensions of synergy management in mergers and acquisitions, common pitfalls, and new models and tools for avoiding them. As such, the book enriches the M&A literature, offers new insights for scholars, and provides valuable guidelines for practitioners involved in synergy management.
Synergy for Clinical Excellence
Synergy for Clinical Excellence - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Synergy for Clinical Excellence write by Roberta Kaplow. This book was released on 2005. Synergy for Clinical Excellence available in PDF, EPUB and Kindle. An essential reference for nursing students in developing and implementing the competencies necessary in caring for critically ill patients. Includes sample test questions relevant to the model that will assist nursing students in preparing for certification through AACN.
Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs
Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs write by John Oleynick. This book was released on 2013. Response Surface Methods for Assessing Synergistic Effects of Three Or More Drugs available in PDF, EPUB and Kindle. Drug synergy occurs when two or more drugs are used in a combination therapy, and the total effect of the drugs is more than would be expected based on their individual effects. Although numerous methods exist for evaluating synergy between two drugs, few have been developed for three or more drugs, and most of them have some significant drawbacks. This dissertation extends a number of two-drug synergy methods to accommodate three or more drugs. First, the method of Plummer and Short [27] is extended to three or more drugs, which is an appropriate method for cases where only global synergy may be present. Next, the parametric method of Kong and Lee [19] is extended, which is appropriate for cases where local synergy may be present. Finally, the semiparametric method of Kong and Lee [20] is extended to three or more drugs, which is an appropriate method for cases where either local synergy may be present or where the model assumptions of the extended Plummer and Short method and the extended Kong and Lee methods are not met. For each method, synergy models are presented for the case of n drugs; the models are then implemented and evaluated using simulated data for the case of three drugs, and their goodness of fit is evaluated using simulations. When more than two drugs are used in a combination, there is an additional complexity not present in 2-drug synergy: determining whether any detected synergy is between all n drugs or only a subset of the drugs. All of the new methods presented in this dissertation are able to make that distinction.
