Extracellular Matrix: Pathobiology and Signaling - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Extracellular Matrix: Pathobiology and Signaling write by Nikos Karamanos. This book was released on 2012-08-31. Extracellular Matrix: Pathobiology and Signaling available in PDF, EPUB and Kindle. Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden
Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology
Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology write by Rajprasad Loganathan. This book was released on 2020-11-19. Extracellular Matrix Dynamics in Biology, Bioengineering, and Pathology available in PDF, EPUB and Kindle. This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Extracellular Matrix: an Overview
The Extracellular Matrix: an Overview - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Extracellular Matrix: an Overview write by Robert Mecham. This book was released on 2011-02-16. The Extracellular Matrix: an Overview available in PDF, EPUB and Kindle. Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Matrix Pathobiology and Angiogenesis
Matrix Pathobiology and Angiogenesis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Matrix Pathobiology and Angiogenesis write by Evangelia Papadimitriou. This book was released on 2022-12-19. Matrix Pathobiology and Angiogenesis available in PDF, EPUB and Kindle. In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Cell-Extracellular Matrix Interactions in Cancer
Cell-Extracellular Matrix Interactions in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cell-Extracellular Matrix Interactions in Cancer write by Roy Zent. This book was released on 2010-01-23. Cell-Extracellular Matrix Interactions in Cancer available in PDF, EPUB and Kindle. Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
