Functional and Structural Proteomics of Glycoproteins - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Functional and Structural Proteomics of Glycoproteins write by Raymond J. Owens. This book was released on 2010-12-02. Functional and Structural Proteomics of Glycoproteins available in PDF, EPUB and Kindle. It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.
Functional and Structural Proteomics of Glycoproteins
Functional and Structural Proteomics of Glycoproteins - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Functional and Structural Proteomics of Glycoproteins write by Raymond J. Owens. This book was released on 2011-04-08. Functional and Structural Proteomics of Glycoproteins available in PDF, EPUB and Kindle. It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.
Mass Spectrometry–Based Glycoproteomics and Its Clinic Application
Mass Spectrometry–Based Glycoproteomics and Its Clinic Application - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry–Based Glycoproteomics and Its Clinic Application write by Haojie Lu. This book was released on 2021-09-20. Mass Spectrometry–Based Glycoproteomics and Its Clinic Application available in PDF, EPUB and Kindle. As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry–Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.
Essentials of Glycobiology
Essentials of Glycobiology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Essentials of Glycobiology write by Ajit Varki. This book was released on 1999. Essentials of Glycobiology available in PDF, EPUB and Kindle. Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Chemical Biology of Glycoproteins
Chemical Biology of Glycoproteins - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Chemical Biology of Glycoproteins write by Zhongping Tan. This book was released on 2017-03-27. Chemical Biology of Glycoproteins available in PDF, EPUB and Kindle. Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.
