Genes, diseases, immunity and immunogenomics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genes, diseases, immunity and immunogenomics write by Hifzur R. Siddique. This book was released on 2023-06-29. Genes, diseases, immunity and immunogenomics available in PDF, EPUB and Kindle.
Immunogenomics and Human Disease
Immunogenomics and Human Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immunogenomics and Human Disease write by Andras Falus. This book was released on 2006-03-30. Immunogenomics and Human Disease available in PDF, EPUB and Kindle. This book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection.
Immunopharmacogenomics
Immunopharmacogenomics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immunopharmacogenomics write by Yusuke Nakamura. This book was released on 2015-09-18. Immunopharmacogenomics available in PDF, EPUB and Kindle. This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.
Genetic Models of Immune and Inflammatory Diseases
Genetic Models of Immune and Inflammatory Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genetic Models of Immune and Inflammatory Diseases write by Abul K. Abbas. This book was released on 2011-09-16. Genetic Models of Immune and Inflammatory Diseases available in PDF, EPUB and Kindle. This book contains the proceedings of the Serono Symposia USA interna tional symposium on Genetic Models of Immune and Inflammatory Dis eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.
Genetic Control of Immune Responsiveness
Genetic Control of Immune Responsiveness - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genetic Control of Immune Responsiveness write by Hugh Mcdevitt. This book was released on 2012-12-02. Genetic Control of Immune Responsiveness available in PDF, EPUB and Kindle. Genetic Control of Immune Responsiveness: Relationship to Disease Susceptibility documents the proceedings of an international conference held at Brook Lodge, Augusta, Michigan, May 8-10, 1972. It brings together the detailed experimental evidence on the mechanism of action of specific immune response genes, and shows how the two major classes of immune response genes affect our understanding of basic immunology and antibody formation on the one hand, and of host factors determining disease susceptibility on the other. The book is organized into seven parts that correspond to the seven sessions of the conference. Part I presents a session on how the study of the genetic control of immune responses in guinea pigs and mice has contributed to the development of T cell immunology. Part II presents a session on genetic fine structure of the major (H-2) histocompatibility complex in the mouse. Part III presents a session dealing with the association between the production of homogeneous antibody, or of idiotypic antibody, and immunoglobulin allotypes. Part IV presents a session on the relationship between histocompatibility-linked and allotype-linked immune response genes and antigen-specific receptors on T and B cells. Part V presents a session on animal models of multigenic control of susceptibility to disease. Part VI presents a session on the associations between HL-A type and specific disease entities. Finally, Part VII provides a commentary on the ideas and concepts emerging from the three days of free-ranging discussion.
