Genetics of Epilepsy and Refractory Epilepsy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genetics of Epilepsy and Refractory Epilepsy write by Alberto Lazarowski. This book was released on 2013-03-01. Genetics of Epilepsy and Refractory Epilepsy available in PDF, EPUB and Kindle. Epilepsy affects approximately 3% of the population, and is usually defined as a tendency to experience recurrent seizures arising from periodic neuronal hyperexcitability of unknown causes. Different genetic factors, through various mechanisms, can cause this abnormal neuronal behavior. The etiology of epilepsy is a major determinant of clinical course and prognosis. Many of the genes that have been implicated in idiopathic epilepsies code for ion channels, whereas a wide spectrum of syndromes where epilepsy is a main clinical feature are caused by mutated genes that are involved in functions as diverse as cortical development, brain malformations, mitochondrial function, and cell metabolism. Similarly, different conditions as hypoxia, trauma, infections, or metabolic unbalances can develop epileptic syndromes where upregulation of several genes could be related to the epileptogenic mechanisms. The most common human genetic epilepsies display a complex pattern of inheritance, and the susceptible genes are largely unknown. However, major advances have recently been made in our understanding of the genetic basis of monogenic inherited epilepsies. As we continue to unravel the molecular genetic basis for epilepsies, it will increasingly influence their classification and diagnosis. A majority of epileptic patients may control their crisis with anticonvulsant drugs, however 30%–40% became refractory to pharmacological therapies and require surgical treatment. The challenge of the molecular revolution will be the design of the best treatment protocols based on genetic profiles that include both the specific mechanistic etiology of the epilepsies, as well as their potential refractory behavior to current medications. This includes also the design of new therapeutic agents and targets, so as to reduce the number of cases with refractory epilepsy and epileptogenesis, and perhaps avoid the current surgical treatment (a procedure that was first described more than 4000 years ago) except as a last option.
The Epilepsies
The Epilepsies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Epilepsies write by Chrysostomos P. Panayiotopoulos. This book was released on 2005. The Epilepsies available in PDF, EPUB and Kindle. This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Genetics of Epilepsy and Genetic Epilepsies
Genetics of Epilepsy and Genetic Epilepsies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genetics of Epilepsy and Genetic Epilepsies write by Giuliano Avanzini. This book was released on 2009. Genetics of Epilepsy and Genetic Epilepsies available in PDF, EPUB and Kindle. This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations. Recent studies on monogenic epilepsies present new insights into mechanisms whereby a mutation of a single gene, coding for an ion channel, can result in a complex epileptic phenotype. The analysis of genetically-determined epileptogenic dysplasia is advancing our understanding of the role of genes in controlling normal and pathological brain development. The pathogenic mechanisms by which gene mutations determine progressive myoclonus epilepsies offer critical opportunities to understand the role of genetic factors in neurodegenerative phenome-na associated with an even broader range of progressive epilepsy types. The specialists who have contributed to this book are outstanding international experts in their respective fields, ensuring first and foremost that the reviews are of relevance to clinicians dealing with epilepsy in their daily practice, as well as providing the highest quality scientific information for biomedical research.
Genetics of Epilepsy
Genetics of Epilepsy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Genetics of Epilepsy write by . This book was released on 2014-09-04. Genetics of Epilepsy available in PDF, EPUB and Kindle. The book chapters cover different aspects of epilepsy genetics, starting with the "classical" concept of epilepsies as ion channel disorders. The second part of the book gives credit to the fact that by now non-ion channel genes are recognized as equally important causes of epilepsy. The concluding chapters are designed to offer the reader insight into current methods in epilepsy research. Each chapter is self-contained and deals with a selected topic of interest. Authors are the leading experts in the field of epilepsy research Book covers the most important aspects of epilepsy Interesting for both scientists and clinicians
Epilepsy
Epilepsy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Epilepsy write by Gregory D. Cascino. This book was released on 2021-02-22. Epilepsy available in PDF, EPUB and Kindle. Designed to provide a comprehensive but accessible introduction to epilepsy and seizure disorders, Epilepsy, 2nd edition provides state-of-the-art information in a concise format useful to a wide audience, from neurology residents to epilepsy fellows and practitioners. This illustrated guide to the assessment, diagnosis, and treatment of epilepsy is a valuable resource enabling clinicians to stay on top of the latest recommendations for best practice.
