Handbook of Drug Metabolism, Third Edition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Drug Metabolism, Third Edition write by Paul G. Pearson. This book was released on 2019-05-20. Handbook of Drug Metabolism, Third Edition available in PDF, EPUB and Kindle. This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Handbook of Drug Metabolism
Handbook of Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Drug Metabolism write by Paul G Pearson. This book was released on 2019-08-30. Handbook of Drug Metabolism available in PDF, EPUB and Kindle. This timely, expanded new edition is the definitive handbook for experienced drug metabolism and pharmaceutical scientists and those new to the field. Written by internationally renowned authors, it provides integrated, comprehensive coverage of fundamental aspects of drug metabolism and the practical applications that help guide researchers through key challenges in modern drug discovery and development. The Second Edition covers the many recent scientific and technical advances in the field, and is organized in four sections - ideal for use in undergraduate and graduate programs in Drug Metabolism and Clinical Pharmacology: fundamental aspects of drug metabolism factors that affect drug metabolism new enabling technologies to study drug metabolism applications of metabolism studies in drug development and drug discovery
Drug Metabolism Handbook
Drug Metabolism Handbook - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism Handbook write by Ala F. Nassar. This book was released on 2009-01-28. Drug Metabolism Handbook available in PDF, EPUB and Kindle. A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.
Handbook of Drug Metabolism
Handbook of Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Handbook of Drug Metabolism write by Thomas F. Woolf. This book was released on 1999. Handbook of Drug Metabolism available in PDF, EPUB and Kindle. Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.
Human Drug Metabolism
Human Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Human Drug Metabolism write by Michael D. Coleman. This book was released on 2020-02-19. Human Drug Metabolism available in PDF, EPUB and Kindle. Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact. Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s. Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate Illustrates the growing relationship between drug metabolism and personalized medicine Includes recent developments in drug discovery, genomics, and stem cell technologies Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.
