High-Throughput Mass Spectrometry in Drug Discovery - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook High-Throughput Mass Spectrometry in Drug Discovery write by Chang Liu. This book was released on 2023-06-29. High-Throughput Mass Spectrometry in Drug Discovery available in PDF, EPUB and Kindle. High-Throughput Mass Spectrometry in Drug Discovery Apply mass spectrometry to every phase of new drug discovery with this cutting-edge guide Mass spectrometry is a technique that identifies and characterizes compounds based on their mass — the fundamental molecular characteristic. It has become an invaluable analytical tool in various disciplines, industries, and research fields. It has become particularly central to new drug discovery and development, which broadly deploys mass spectrometry at every phase. The pharmaceutical industry has become one of the main drivers of technological development in mass spectrometry. High-Throughput Mass Spectrometry in Drug Discovery offers a comprehensive introduction to mass spectrometry and its applications in pharmaceutical discovery. It covers the foundational principles and science of mass spectrometry before moving to specific experimental methods and their applications at various stages of drug discovery. Its thorough treatment and detailed guidance make it an invaluable tool for pharmaceutical research and development. High-Throughput Mass Spectrometry in Drug Discovery readers will also find: Detailed analysis of techniques, including label-free screening, synthetic reaction optimization, and more An authorial team with extensive combined experience in research and industrial applications Technical strategies with the potential to accelerate quantitative bioanalysis in drug discovery High-Throughput Mass Spectrometry in Drug Discovery is essential for analytical, bioanalytical, and medicinal chemists working in the pharmaceutical industry and for any researchers and graduate students interested in drug discovery and development.
High-Throughput Analysis in the Pharmaceutical Industry
High-Throughput Analysis in the Pharmaceutical Industry - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook High-Throughput Analysis in the Pharmaceutical Industry write by Perry G. Wang. This book was released on 2008-08-20. High-Throughput Analysis in the Pharmaceutical Industry available in PDF, EPUB and Kindle. The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres
Mass Spectrometry in Medicinal Chemistry
Mass Spectrometry in Medicinal Chemistry - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Medicinal Chemistry write by Klaus Wanner. This book was released on 2007-06-27. Mass Spectrometry in Medicinal Chemistry available in PDF, EPUB and Kindle. This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Mass Spectrometry in Drug Metabolism and Pharmacokinetics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Drug Metabolism and Pharmacokinetics write by Ragu Ramanathan. This book was released on 2011-09-20. Mass Spectrometry in Drug Metabolism and Pharmacokinetics available in PDF, EPUB and Kindle. This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Integrated Strategies for Drug Discovery Using Mass Spectrometry
Integrated Strategies for Drug Discovery Using Mass Spectrometry - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Integrated Strategies for Drug Discovery Using Mass Spectrometry write by Mike S. Lee. This book was released on 2005-09-02. Integrated Strategies for Drug Discovery Using Mass Spectrometry available in PDF, EPUB and Kindle. New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples
