How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? write by Antoine Toubert. This book was released on 2015-03-12. How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? available in PDF, EPUB and Kindle. Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution. This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Holland-Frei Cancer Medicine write by Robert C. Bast, Jr.. This book was released on 2017-03-10. Holland-Frei Cancer Medicine available in PDF, EPUB and Kindle. Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation write by Gerard Socie. This book was released on 2018-11-22. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation available in PDF, EPUB and Kindle. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation
Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation write by Brigitta Omazic. This book was released on 2004. Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation available in PDF, EPUB and Kindle.
Assessment of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation
Assessment of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Assessment of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation write by Meenakshi Singh. This book was released on 2020. Assessment of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation available in PDF, EPUB and Kindle. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential curative treatment for both congenital and hematological malignancies. Immune reconstitution after allogeneic hematopoietic stem cell transplantation is implicated in successful transplant outcomes such as overall survival and relapse-free survival. The reconstitution of immune cell subsets after HSCT occurs in different phases at different time points encompassing pre-engraftment, engraftment, and post-engraftment. The recovery of innate cellular immunity with the appearance of monocytes, dendritic cells, and natural killer cells in peripheral blood correlates with initiation of cellular engraftment. The cellular adaptive immunity is characterized by both thymic-independent expansion of T cells infused with graft and thymus-dependent expansion of naïve T cells derived from donor stem cells. The humoral immunity consists of B-cell reconstitution, which consists primarily of transitional and naïve subsets with the recovery of memory B cells that occur much later. In this review, we highlight the factors affecting immune reconstitution, the reconstitution of innate and adaptive immunity, techniques to assess immune reconstitution, and ways to enhance it.
