HSF1 and Molecular Chaperones in Biology and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook HSF1 and Molecular Chaperones in Biology and Cancer write by Marc Laurence Mendillo. This book was released on 2020-04-15. HSF1 and Molecular Chaperones in Biology and Cancer available in PDF, EPUB and Kindle. Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Heat Shock Proteins in Cancer
Heat Shock Proteins in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Heat Shock Proteins in Cancer write by Stuart K. Calderwood. This book was released on 2007-09-09. Heat Shock Proteins in Cancer available in PDF, EPUB and Kindle. Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks write by Peter Csermely. This book was released on 2007-08-09. Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks available in PDF, EPUB and Kindle. This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Hsp90 in Cancer: Beyond the Usual Suspects
Hsp90 in Cancer: Beyond the Usual Suspects - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Hsp90 in Cancer: Beyond the Usual Suspects write by . This book was released on 2016-02-23. Hsp90 in Cancer: Beyond the Usual Suspects available in PDF, EPUB and Kindle. Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. - Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins - Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology - Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression
Mitochondria and Cancer
Mitochondria and Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mitochondria and Cancer write by Keshav Singh. This book was released on 2009-04-05. Mitochondria and Cancer available in PDF, EPUB and Kindle. Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
