Hydrolysis in Drug and Prodrug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Hydrolysis in Drug and Prodrug Metabolism write by Bernard Testa. This book was released on 2003-08. Hydrolysis in Drug and Prodrug Metabolism available in PDF, EPUB and Kindle. Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Prodrugs
Prodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Prodrugs write by Valentino Stella. This book was released on 2007-03-12. Prodrugs available in PDF, EPUB and Kindle. These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.
Concepts in Biochemical Pharmacology
Concepts in Biochemical Pharmacology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Concepts in Biochemical Pharmacology write by P.S. Randall. This book was released on 2013-11-27. Concepts in Biochemical Pharmacology available in PDF, EPUB and Kindle. Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.
Design of Prodrugs
Design of Prodrugs - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Design of Prodrugs write by Hans Bundgaard. This book was released on 1985. Design of Prodrugs available in PDF, EPUB and Kindle.
Drug Metabolism
Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism write by Corina Ionescu. This book was released on 2006-02-28. Drug Metabolism available in PDF, EPUB and Kindle. Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
