Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters write by Shuguang Ma. This book was released on 2020-07-09. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters available in PDF, EPUB and Kindle. Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. - Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues - Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included - Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics - All chapters are written by experts with a wide range of practical experience from the industry and academia
Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS
Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS write by Swapan Chowdhury. This book was released on 2005-11-04. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS available in PDF, EPUB and Kindle. As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners.* Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies·* Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them* Highlights problems associated with drug quantification and offers practical solutions
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug Metabolism, Pharmacokinetics and Bioanalysis - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism, Pharmacokinetics and Bioanalysis write by Hye Suk Lee. This book was released on 2019-06-12. Drug Metabolism, Pharmacokinetics and Bioanalysis available in PDF, EPUB and Kindle. Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Drug Transporters
Drug Transporters - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Transporters write by Martin F. Fromm. This book was released on 2010-11-19. Drug Transporters available in PDF, EPUB and Kindle. It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
Drug Metabolism and Pharmacokinetics Quick Guide
Drug Metabolism and Pharmacokinetics Quick Guide - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug Metabolism and Pharmacokinetics Quick Guide write by Siamak Cyrus Khojasteh. This book was released on 2011-04-07. Drug Metabolism and Pharmacokinetics Quick Guide available in PDF, EPUB and Kindle. Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
