Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I write by Chang Gu. This book was released on 2023-10-20. Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I available in PDF, EPUB and Kindle. During the past few decades, immunotherapy has become an established pillar of cancer treatment improving the survival of numerous patients with diverse solid and hematologic tumors. The leading causes behind the success are the discovery of immune checkpoint inhibitors (ICIs) and the development of chimeric antigen receptor (CAR) T/M/NK cells. As for ICIs, malignancies take advantage of the inhibitory programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) or cytotoxic T-lymphocyte-associated protein (CTLA-4) pathways to evade the immune system, and disruption of the axis by immune checkpoint inhibitors can achieve durable disease remissions, which has been proved by basic researches and (pre-) clinical studies among lung cancer, melanoma, renal cell cancer, head, and neck squamous cell carcinoma, urothelial cancer, and Hodgkin’s disease. However, the 5-year survival rate of patients treated with ICIs varies with each individual and also relies on tumor specific pathological or molecular subtypes. Besides, the efficacy of ICIs is still limited in terms of drug resistance and fewer potential responders. Thus, there is a big challenge to identify and develop more novel reliable ICIs, as well as sensibilize existing ICIs for patients with drug resistance or even for non-responders.
Cancer Immunology
Cancer Immunology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Cancer Immunology write by . This book was released on 2021. Cancer Immunology available in PDF, EPUB and Kindle. This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.
Biomarkers in Cancer Screening and Early Detection
Biomarkers in Cancer Screening and Early Detection - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomarkers in Cancer Screening and Early Detection write by Sudhir Srivastava. This book was released on 2017-06-05. Biomarkers in Cancer Screening and Early Detection available in PDF, EPUB and Kindle. Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information and hopefully also inspiration to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers
Biomarkers for Immunotherapy of Cancer
Biomarkers for Immunotherapy of Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Biomarkers for Immunotherapy of Cancer write by Magdalena Thurin. This book was released on 2019-09-10. Biomarkers for Immunotherapy of Cancer available in PDF, EPUB and Kindle. This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II
Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II write by . This book was released on 2024-01-10. Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy, volume II available in PDF, EPUB and Kindle. This Research Topic is the second volume of the “Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy". Please see Volume I here. Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy. This research topic aims to focus on the advances in the discoveries of novel biomarkers for predicting response to cancer immunotherapy in various tumors. We welcome the submission of original research and review articles that include biomarkers in clinical study and applications, as well as technologies or discoveries in experimental approaches.
