Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation in Children - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation in Children write by . This book was released on 2019. Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation in Children available in PDF, EPUB and Kindle.
Immune Reconstruction After Allogeneic Bone Marrow Transplantation In Pediatric Patients
Immune Reconstruction After Allogeneic Bone Marrow Transplantation In Pediatric Patients - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Reconstruction After Allogeneic Bone Marrow Transplantation In Pediatric Patients write by Popa Delia Codruta. This book was released on 2017. Immune Reconstruction After Allogeneic Bone Marrow Transplantation In Pediatric Patients available in PDF, EPUB and Kindle. CONTEXT: Allogeneic hematopoietic stem cell transplantation (HSCT) has become a well-defined therapeutic strategy for a wide variety of malignant and non-malignant diseases with curative potential. Immune reconstitution post-HSCT is a complex and dynamic process, achieved in stages, depending on the type of transplant, the characteristics of the donor and the recipient, and the occurrence and stage of the graft versus host disease (GvHD).OBJECTIVE: The objective of our study is to identify the correlations between regenerating cell lineage and the time required for complete reconstitution of the immune status depending on the type of allogeneic transplantation.DESIGN: We retrospectively evaluated 16 patients, who have been undergoing allogeneic transplantation between January 2015 and March 2018, and who survived at least 100 days after transplantation in the Pediatric Department, Fundeni Clinical Institute, Bucharest. We analyzed the immune status (B, T and NK cells) by immunophenotyping, using the following markers: Lambda, Kappa, CD56, CD5, CD19, TCRgd/CD16, CD3, CD38, CD20, CD8, CD4, CD45 at well-defined checkpoint intervals (3, 6, 9, 12, and 24 months after the transplant). Absolute values of each subgroup were calculated using the percentage of each subset and absolute count from the leukocytes. RESULTS: In this study, 16 patients have been undergoing allogeneic HSCT transplantation for malignant and non-malignant diseases. There were achieved 5 haploidentical HSCT, 8 HSTC from a matched unrelated donor (MUD), and 4 matched sibling donor (MSD). 5 patients experienced immune recovery during the first 6 months, the NK cells subset has reconstituted in the first 3 months, and the last one to recover was the T cells subset (CD4+). In our study group, the immune reconstitution rate was 20% for haploidentical transplantation, 37.5% for MUD and 25% for MSD. Moreover, delayed immune reconstitution has been associated with the occurrence/reactivation of viral infections (CMV, EBV, BKV, and JCV) with increased frequency in the post-grafting period.CONCLUSIONS: In our center, patients undergoing transplantation from MSD have the fastest immune reconstitution. The immune reconstitution of patients after allogeneic HSCT influences long-term survival by contributing to the management of infectious complications and of GvHD.
Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation
Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation write by Brigitta Omazic. This book was released on 2004. Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation available in PDF, EPUB and Kindle.
Immunological Challenges Following Pediatric Hematopoietic Transplantation
Immunological Challenges Following Pediatric Hematopoietic Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immunological Challenges Following Pediatric Hematopoietic Transplantation write by Robert James Hayashi. This book was released on 2021-09-28. Immunological Challenges Following Pediatric Hematopoietic Transplantation available in PDF, EPUB and Kindle.
How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation?
How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? write by Antoine Toubert. This book was released on 2015-03-12. How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? available in PDF, EPUB and Kindle. Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects. Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution. This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
