Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation write by Dominik Schneidawind. This book was released on 2020-05-22. Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation available in PDF, EPUB and Kindle.
Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD
Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD write by Natalie Köhler. This book was released on 2019. Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD available in PDF, EPUB and Kindle.
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation
Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation write by Gerard Socie. This book was released on 2018-11-22. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation available in PDF, EPUB and Kindle. Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications
Achievement of Transplantation Tolerance
Achievement of Transplantation Tolerance - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Achievement of Transplantation Tolerance write by Joseph Pidala. This book was released on 2014. Achievement of Transplantation Tolerance available in PDF, EPUB and Kindle. Current immune suppressive strategies fail to induce donor-recipient immune tolerance after allogeneic hematopoietic cell transplantation. Accordingly, patients suffer morbidity and mortality from graft vs. host disease (GVHD) and prolonged immune suppressive therapy. Biologic insight into transplantation tolerance is needed, and translation of such insight to novel clinical strategies may improve clinical outcomes. We report original investigation at seminal phases of this process including initial prophylactic immune suppression, onset of acute graft vs. host disease, and ultimate immune suppression discontinuation: In a controlled randomized clinical trial, we demonstrate that sirolimus-based immune suppression reduces risk for acute GVHD, ameliorates the severity of subsequent chronic GVHD, and supports reconstitution of functional regulatory T cells. Study of tissue-infiltrating CD4+ T cell subsets in acute GVHD target organs supports a pathogenic role for Th17 cells. Finally, we demonstrate that peripheral blood transcriptional biomarkers provide mechanistic insight into human transplantation tolerance. These data signal progress, and suggest rational translational efforts to achieve transplantation tolerance.
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases write by Richard K. Burt. This book was released on 2021-11-17. Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases available in PDF, EPUB and Kindle. This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
