Induction of Central Nervous System Disease by the Adaptive Immune Response - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Induction of Central Nervous System Disease by the Adaptive Immune Response write by Robert Weissert. This book was released on 2017-11-23. Induction of Central Nervous System Disease by the Adaptive Immune Response available in PDF, EPUB and Kindle. Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.
Protective and Pathological Immune Responses in the CNS
Protective and Pathological Immune Responses in the CNS - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Protective and Pathological Immune Responses in the CNS write by B. Dietzschold. This book was released on 2013-11-11. Protective and Pathological Immune Responses in the CNS available in PDF, EPUB and Kindle. In spite of the protection of the CNS there are situations where immune responses occur due to different disease processes. While antigen-specific cells of the adaptive immune response are not normally functional in the CNS tissue, CNS resident cells respond to infection or insult. One mechanisms is through the induction of apoptosis in virus infected neurons, which may be protective or pathogenic depending on the extent of cell death.
Molecular Biology of The Cell
Molecular Biology of The Cell - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Molecular Biology of The Cell write by Bruce Alberts. This book was released on 2002. Molecular Biology of The Cell available in PDF, EPUB and Kindle.
Brain Neurotrauma
Brain Neurotrauma - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Brain Neurotrauma write by Firas H. Kobeissy. This book was released on 2015-02-25. Brain Neurotrauma available in PDF, EPUB and Kindle. With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity
Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity write by C. Jane Welsh. This book was released on 2007-04-05. Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity available in PDF, EPUB and Kindle. This book provides a lucid summary of behavioral, neural and endocrine regulation of immune responses and of the effects of immune system activity on neural and endocrine functions and behavior. The underlying premise is that the brain and immune system represent a single, integrated system of defense. The discussion includes such topics and stress induced modulation of innate resistance and adaptive immunity in influenza viral infections.
