Inhibiting PARP as a Strategic Target in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inhibiting PARP as a Strategic Target in Cancer write by Christina Annunziata. This book was released on 2016-08-05. Inhibiting PARP as a Strategic Target in Cancer available in PDF, EPUB and Kindle. Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
Inhibiting PARP as a Strategic Target in Cancer
Inhibiting PARP as a Strategic Target in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Inhibiting PARP as a Strategic Target in Cancer write by . This book was released on 2016. Inhibiting PARP as a Strategic Target in Cancer available in PDF, EPUB and Kindle. Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook PARP Inhibitors for Cancer Therapy write by Nicola J. Curtin. This book was released on 2015-06-13. PARP Inhibitors for Cancer Therapy available in PDF, EPUB and Kindle. PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
Signal Transduction in Cancer
Signal Transduction in Cancer - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Signal Transduction in Cancer write by David A. Frank. This book was released on 2002-12-31. Signal Transduction in Cancer available in PDF, EPUB and Kindle. One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Poly(ADP-Ribosyl)ation
Poly(ADP-Ribosyl)ation - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Poly(ADP-Ribosyl)ation write by Alexander Bürkle. This book was released on 2008-01-11. Poly(ADP-Ribosyl)ation available in PDF, EPUB and Kindle. This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.
