Metal Complex - DNA Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Metal Complex - DNA Interactions write by Nick Hadjiliadis. This book was released on 2009-03-30. Metal Complex - DNA Interactions available in PDF, EPUB and Kindle. Metal ions and metal complexes have long been recognized ascritically important components of nucleic acid chemistry, both inregulation of gene expression and as promising therapeutic agents.Understanding how metal complexes interact with DNA has become anactive research area at the interface between chemistry, molecularbiology and medicine. Metal Complex - DNA Interactions provides a comprehensiveoverview of this increasingly diverse field, presenting recentdevelopments and the latest research with particular emphasis onmetal-based drugs and metal ion toxicity. The text is divided intofour parts: Basic Structural and Kinetic Aspects: includes chapterson sequence-selective metal binding to DNA and thermodynamicmodels. Medical Applications: focuses on anticancer platinumdrugs, including discussions on DNA repair in antitumor effects ofplatinum drugs and photo-dynamic therapy. DNA-Recognition - Nucleases and Sensor: describesprobes for DNA recognition, artificial restriction agents,metallo-DNAzymes for metal sensing applications and metal iondependent catalysis in nucleic acid enzymes. Toxicological Aspects: deals with structural studies ofmercury–DNA interactions, chromium-induced DNA damage andrepair, and the effect of arsenic and nickel on DNAintegrity. This book will be a valuable resource for academic researchersand professionals from a range of pharmaceutical and chemicalindustries, particularly those involved in the development of newand less toxic anticancer metallo-drugs, and in the field ofenvironmental and toxicological chemistry.
Interactions of Metal Complexes with DNA
Interactions of Metal Complexes with DNA - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Interactions of Metal Complexes with DNA write by Jihan Talib. This book was released on 2008. Interactions of Metal Complexes with DNA available in PDF, EPUB and Kindle.
Drug-DNA Interactions
Drug-DNA Interactions - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Drug-DNA Interactions write by Kazuo Nakamoto. This book was released on 2008-09-08. Drug-DNA Interactions available in PDF, EPUB and Kindle. Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
DNA-targeting Molecules as Therapeutic Agents
DNA-targeting Molecules as Therapeutic Agents - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook DNA-targeting Molecules as Therapeutic Agents write by Michael J Waring. This book was released on 2018-03-08. DNA-targeting Molecules as Therapeutic Agents available in PDF, EPUB and Kindle. There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
Transition Metal Complexes as Drugs and Chemotherapeutic Agents
Transition Metal Complexes as Drugs and Chemotherapeutic Agents - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Transition Metal Complexes as Drugs and Chemotherapeutic Agents write by N. Farrell. This book was released on 2012-12-06. Transition Metal Complexes as Drugs and Chemotherapeutic Agents available in PDF, EPUB and Kindle. When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica tion of the manuscript. The introduction contains an explanation of the layout and approach to the book, which I wrote as an overall survey of the wide variety of biological properties of metal complexes. Hopefully, the reader will see the parallels in mechanisms and behavior, even in different organisms. The writing was considerably helped by the enthusiasm and confidence (totally unearned on my part) in the project of Professor Brian James and lowe him my special thanks. I also owe a great debt of gratitude to my colleagues, and especially to Eucler Paniago, of the Universidade Federal de Minas Gerais, for their comprehension and for the initial leave of absence which allowed me to begin the project. To those who read some or all of the manuscript and made suggestions, Bernhard Lippert, Kirsten Skov, and Tom Tritton, as well as the editor's reviewer I am also grateful. As usual, the final responsibility for errors or otherwise rests with the author.
