Male-Mediated Developmental Toxicity - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Male-Mediated Developmental Toxicity write by Andrew F. Olshan. This book was released on 2012-12-06. Male-Mediated Developmental Toxicity available in PDF, EPUB and Kindle. The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.
Advances in Male Mediated Developmental Toxicity
Advances in Male Mediated Developmental Toxicity - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Advances in Male Mediated Developmental Toxicity write by Bernard Robaire. This book was released on 2012-12-06. Advances in Male Mediated Developmental Toxicity available in PDF, EPUB and Kindle. This volume highlights major contributions that identify new developments and directions in the field over the past decade, as well as challenges for the foreseeable future. An integration of information from laboratory and epidemiological studies, male reproduction and teratology can be found throughout the volume. The range of topics include parental legacies and genomics, lifestyle, occupational and therapeutic paternal exposures and effects; effects on the gamete-packaging of human sperm; role of DNA repair and germ cell apoptosis; stem cells, epigenetics and closing; model systems and implications to clinicians and general counselors.
Male-mediated Developmental Toxicity
Male-mediated Developmental Toxicity - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Male-mediated Developmental Toxicity write by Diana Anderson. This book was released on 2007. Male-mediated Developmental Toxicity available in PDF, EPUB and Kindle. Male germ line mutagenesis and the effects on developmental defects in the next generation.
Scientific Frontiers in Developmental Toxicology and Risk Assessment
Scientific Frontiers in Developmental Toxicology and Risk Assessment - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Scientific Frontiers in Developmental Toxicology and Risk Assessment write by National Research Council. This book was released on 2000-11-21. Scientific Frontiers in Developmental Toxicology and Risk Assessment available in PDF, EPUB and Kindle. Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
An Investigation of the Herbicide Formulation, Tordon 75D® and Male-mediated Developmental Toxicity
An Investigation of the Herbicide Formulation, Tordon 75D® and Male-mediated Developmental Toxicity - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook An Investigation of the Herbicide Formulation, Tordon 75D® and Male-mediated Developmental Toxicity write by Diana Joy Oakes. This book was released on 2000. An Investigation of the Herbicide Formulation, Tordon 75D® and Male-mediated Developmental Toxicity available in PDF, EPUB and Kindle.
