Using Mass Spectrometry for Drug Metabolism Studies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Using Mass Spectrometry for Drug Metabolism Studies write by Walter A. Korfmacher. This book was released on 2004-12-17. Using Mass Spectrometry for Drug Metabolism Studies available in PDF, EPUB and Kindle. Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field. Using Mass Spectrometry
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Mass Spectrometry in Drug Metabolism and Pharmacokinetics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Drug Metabolism and Pharmacokinetics write by Ragu Ramanathan. This book was released on 2011-09-20. Mass Spectrometry in Drug Metabolism and Pharmacokinetics available in PDF, EPUB and Kindle. This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Mass Spectrometry in Drug Metabolism
Mass Spectrometry in Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Drug Metabolism write by Frigerio. This book was released on 2012-12-06. Mass Spectrometry in Drug Metabolism available in PDF, EPUB and Kindle. When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmaco kinetic" phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or "pharmacodynamic" phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reasons: only a minimal amount of sample preparation is needed, closely related compounds can be analyzed in a single step, structures can often be deduced directly from the mass spectra without the need for pure reference spectra, and constituents can be quantified with relative ease even when present in fractional nanogram quantity.
Mass Spectrometry in Drug Metabolism and Disposition
Mass Spectrometry in Drug Metabolism and Disposition - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Drug Metabolism and Disposition write by Mike S. Lee. This book was released on 2011-03-16. Mass Spectrometry in Drug Metabolism and Disposition available in PDF, EPUB and Kindle. This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Mass Spectrometry in Drug Metabolism
Mass Spectrometry in Drug Metabolism - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mass Spectrometry in Drug Metabolism write by Alberto Frigerio. This book was released on 1976. Mass Spectrometry in Drug Metabolism available in PDF, EPUB and Kindle.
