Mechanical Forces and the Endothelium - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanical Forces and the Endothelium write by Michael A Gimbrone. This book was released on 1999-08-19. Mechanical Forces and the Endothelium available in PDF, EPUB and Kindle. Areas addressed in this excellent text include the overall response of the endothelium to hemodynamic forces, and molecular biology with gene regulation taking a central role.
Mechanical Forces: Their Effects on Cells and Tissues
Mechanical Forces: Their Effects on Cells and Tissues - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanical Forces: Their Effects on Cells and Tissues write by Keith J. Gooch. This book was released on 2013-03-14. Mechanical Forces: Their Effects on Cells and Tissues available in PDF, EPUB and Kindle. Animal Cell Culture nimal cell culture began in 1912 when Alexis Carrel grew bits of chick heart A in vitro by placing them into a drop of horse plasma. When the plasma clotted, it formed a solid surface into which the heart cells explanted. Left unattended, these cells died within several days. By regularly feeding the grow ing cells with aqueous extracts of whole chick embryos and periodically sub dividing them, Carrel was able to maintain the cells for extended periods. From these initial experiments, cell culture has expanded into an important component of biological research and commercial production. Animal cell culture is an important tool for the study of complex biologi cal systems. In vivo it is often impossible to target a treatment to one specific cell type or to adequately control the environment. For example, it is impos sible to selectively depolarize endothelial cells in vivo to determine the role of transmembrane potential in the transduction of fluid mechanical forces generated by blood flow to a biochemical response. Depolarizing all of the cells within the vascular system by injecting potassium chloride into the animal's bloodstream clearly is not an option, as it will lead to cardiac arrest.
The Endothelium
The Endothelium - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook The Endothelium write by Michel Félétou. This book was released on 2011. The Endothelium available in PDF, EPUB and Kindle. The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades write by Wolfgang B. Liedtke, MD, PH.D.. This book was released on 2006-09-29. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades available in PDF, EPUB and Kindle. Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Mechanisms of Vascular Disease
Mechanisms of Vascular Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanisms of Vascular Disease write by Robert Fitridge. This book was released on 2011. Mechanisms of Vascular Disease available in PDF, EPUB and Kindle. New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
