Mechanisms of Secondary Brain Damage - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanisms of Secondary Brain Damage write by A. Baethmann. This book was released on 2013-03-09. Mechanisms of Secondary Brain Damage available in PDF, EPUB and Kindle. A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
Mechanisms of Secondary Brain Damage from Trauma and Ischemia
Mechanisms of Secondary Brain Damage from Trauma and Ischemia - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanisms of Secondary Brain Damage from Trauma and Ischemia write by A. Baethmann. This book was released on 2012-12-06. Mechanisms of Secondary Brain Damage from Trauma and Ischemia available in PDF, EPUB and Kindle. Top level clinical and laboratory scientists present their most recent clinical and experimental findings and concepts. The well balanced contributions illustrate the enormous significance of the dialogue between both laboratory and clinic, ultimately for the benefit of the patients, and contribute to a better understanding of secondary brain damage from trauma and ischemia as basis to develop more effective treatment including drugs.
Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma
Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma write by Alexander Baethmann. This book was released on 2012-12-06. Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma available in PDF, EPUB and Kindle. The publication of the Vth International Symposium 1995 on "Mechanisms of Secondary Brain Damage" in Mauls/ltaly is a collection of focused reviews reaching from novel molecular- and cell biological findings to aspects of clinical management in head injury and cerebral ischemia. A specific purpose of these series of meetings introduced in 1984 is for an exchange on problems of mutual interest by international high ranking experts from the basic sciences and related clinical disciplines, such as intensive care medicine, neurology, or neurosurgery. The present volume covers three major areas: (a) Molecular and cell biological mechanisms including inflammation (b) Novel findings on mechanisms and treatment in cerebral ischemia (c) Secondary processes in head injury, regeneration and treatment Molecular-and cell biology is currently attracting attention towards activation of genomic processes associated with the demise of cells referred to as "programmed cell death" and "apoptosis" which, actually, might be distinguished from each other. Thus, the phenomenon of delayed neuronal death in selectively vulnerable brain areas following brief interruption of blood flow is scrutinized as to the contribution of the activation of suicide genes. The physiological role of such a response, among others, is removal of surplus neurons during ontogenesis of the brain. Yet, evidence is accumulating that similar mechanisms playa role in cerebral ischemia, probably also trauma, where nerve-and other cells demonstrate features of apoptosis. Observations on protection of neurons by administration of protein synthesis inhibitors in cerebral ischemia provide more direct support.
Translational Research in Traumatic Brain Injury
Translational Research in Traumatic Brain Injury - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Translational Research in Traumatic Brain Injury write by Daniel Laskowitz. This book was released on 2016-04-21. Translational Research in Traumatic Brain Injury available in PDF, EPUB and Kindle. Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia
Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia write by A. Baethmann. This book was released on 2012-12-06. Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia available in PDF, EPUB and Kindle. Information is provided from the basic and clinical sciences on the mechanisms damaging the brain from trauma or ischemia. New aspects involve the endoplasmic reticulum, mitochondrial failure, pathobiology of axonal injury, molecular signals activating glial elements, or the emerging therapeutical role of neurotrophins. Experimental issues involve a better analysis of the ischemic penumbra, the salvagable tissue. Therapeutic contributions reach from the environmental influence to gene expression, including neuroprotection, such as hibernation – mother nature’s experiment – or hypothermia which is reported to induce cell swelling. Treatment issues deal also with thrombolysis and combination therapies, or with the clearance of adverse blood components – LDL/fibrinogen – by a novel procedure using heparin. Other highlights are discussing the specificities of pediatric vs. adult brain trauma, or the evolving role of the Apolipoprotein-E e4 gene in severe head injury. An update is also provided on an online assessment of the patient management during the pre- and early hospital phase in Southern Bavaria. The empirical observation of neuroworsening is analyzed in further details, whether this is a specificity autonomously driving the posttraumatic course. Finally, the unsolved question why drug trials in severe head injury have failed so far in view of the promising evidence from the laboratory is subjected to an expert analysis.
