Metals and Neurodegeneration: Restoring the Balance - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Metals and Neurodegeneration: Restoring the Balance write by Anthony R. White. This book was released on 2016-02-02. Metals and Neurodegeneration: Restoring the Balance available in PDF, EPUB and Kindle. Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.
Phytopharmaceuticals for Brain Health
Phytopharmaceuticals for Brain Health - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Phytopharmaceuticals for Brain Health write by Shahnaz Subhan. This book was released on 2017-09-27. Phytopharmaceuticals for Brain Health available in PDF, EPUB and Kindle. Research studies demonstrate diet and proper nutrition in conjunction with cognitive, mental, social, and physical activities can significantly help in improving brain health with advancing age, and potentially reduce the risk of cognitive decline. These studies of phytopharmaceuticals and medicinal plants, demonstrate the efficacy of Huperzine A, berry anthocyanins, trans-resveratrol, Ginkgo biloba, Bacopa monniera, Centella asiatica, tocotrienols, and palm oil in boosting brain health and physical well-being. In addition, consumption of marine fishes and general seafood is recommended for long-term nutritional intervention to preserve mental health, hinder neurodegenerative processes, and sustain cognitive capacities in humans. Omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, flavonoids, and antioxidants prevent the initiation and progression of many neurological disorders. This book is a comprehensive review of phytopharmaceuticals impacting brain health with emphasis on diverse applications in food and nutrition sciences, biomedicine, neurology and other scientific and medical fields. It details available methods and contains numerous references making this the perfect guide for scientists who want to explore the fascinating world of phytopharmaceuticals with relation to brain health. Phytopharmaceuticals for Brain Health appeals to a diverse range of readers in industry, medical doctors, research and academia, including biologists, biochemists, food scientists, nutritionists and health professionals. Overall, this book brings a classic scenario of neurological problems to possible amelioration using novel nutraceuticals and functional foods.
Brain-Iron Cross Talk
Brain-Iron Cross Talk - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Brain-Iron Cross Talk write by Wael Mohamed. This book was released on 2022-12-16. Brain-Iron Cross Talk available in PDF, EPUB and Kindle. This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.
Metal-Based Neurodegeneration
Metal-Based Neurodegeneration - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Metal-Based Neurodegeneration write by Robert Crichton. This book was released on 2013-09-04. Metal-Based Neurodegeneration available in PDF, EPUB and Kindle. Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
Etiology of Parkinson's Disease
Etiology of Parkinson's Disease - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Etiology of Parkinson's Disease write by Jonas H. Ellenberg. This book was released on 1995-03-01. Etiology of Parkinson's Disease available in PDF, EPUB and Kindle. This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
