Planning and Analyzing Clinical Trials with Composite Endpoints - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Planning and Analyzing Clinical Trials with Composite Endpoints write by Geraldine Rauch. This book was released on 2018-05-22. Planning and Analyzing Clinical Trials with Composite Endpoints available in PDF, EPUB and Kindle. This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results. Composite endpoints are often used as primary efficacy variables for clinical trials, particularly in the fields of oncology and cardiology. These endpoints combine several variables of interest within a single composite measure, and as a result, all variables that are of major clinical relevance can be considered in the primary analysis without the need to adjust for multiplicity. Moreover, composite endpoints are intended to increase the size of the expected effects thus making clinical trials more powerful. The book offers practical advice for statisticians and medical experts involved in the planning and analysis of clinical trials. For readers who are mainly interested in the application of the methods, all the approaches are illustrated with real-world clinical trial examples, and the software codes required for fast and easy implementation are provided. The book also discusses all the methods in the context of relevant guidelines related to the topic. To benefit most from the book, readers should be familiar with the principles of clinical trials and basic statistical methods.
Methods for Planning and Analyzing Clinical Trials with Composite Endpoints
Methods for Planning and Analyzing Clinical Trials with Composite Endpoints - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Methods for Planning and Analyzing Clinical Trials with Composite Endpoints write by Svenja Schüler. This book was released on 2020. Methods for Planning and Analyzing Clinical Trials with Composite Endpoints available in PDF, EPUB and Kindle.
Methods for Planning and Evaluating Clinical Trials with Composite Endpoints
Methods for Planning and Evaluating Clinical Trials with Composite Endpoints - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Methods for Planning and Evaluating Clinical Trials with Composite Endpoints write by Geraldine Rauch. This book was released on 2014. Methods for Planning and Evaluating Clinical Trials with Composite Endpoints available in PDF, EPUB and Kindle.
Sharing Clinical Trial Data
Sharing Clinical Trial Data - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Sharing Clinical Trial Data write by Institute of Medicine. This book was released on 2015-04-20. Sharing Clinical Trial Data available in PDF, EPUB and Kindle. Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Multiple Analyses in Clinical Trials
Multiple Analyses in Clinical Trials - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook Multiple Analyses in Clinical Trials write by Lemuel A. Moyé. This book was released on 2006-05-17. Multiple Analyses in Clinical Trials available in PDF, EPUB and Kindle. Concentrating on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets, this book will help clinical investigators understand multiple analysis procedures and key issues. It is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal level, and biostatisticians.
