MicroRNA Interference Technologies - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNA Interference Technologies write by Zhiguo Wang. This book was released on 2009-06-11. MicroRNA Interference Technologies available in PDF, EPUB and Kindle. MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.
RNA Technologies and Their Applications
RNA Technologies and Their Applications - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA Technologies and Their Applications write by Volker A. Erdmann. This book was released on 2010-09-02. RNA Technologies and Their Applications available in PDF, EPUB and Kindle. RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
RNA Interference from Biology to Therapeutics
RNA Interference from Biology to Therapeutics - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNA Interference from Biology to Therapeutics write by Kenneth A. Howard. This book was released on 2012-10-19. RNA Interference from Biology to Therapeutics available in PDF, EPUB and Kindle. The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
RNAi Technology
RNAi Technology - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook RNAi Technology write by R. K. Gaur. This book was released on 2016-04-19. RNAi Technology available in PDF, EPUB and Kindle. RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
MicroRNA Protocols
MicroRNA Protocols - read free eBook in online reader or directly download on the web page. Select files or add your book in reader. Download and read online ebook MicroRNA Protocols write by Shao-Yao Ying. This book was released on 2008-02-04. MicroRNA Protocols available in PDF, EPUB and Kindle. MicroRNA Protocols provides diverse, novel, and useful descriptions of miRNAs in several species, including plants, worms, flies, fish, chicks, mice, and humans. These include some useful adaptations and applications that could be relevant to the wider research community who are already familiar with the identification of miRNAs. This volume will stimulate the reader to explore diverse ways to understanding the mechanism in which miRNAs facilitate the molecular aspects of the biomedical research.
